Pediatric brain tumors in a low/middle income country: does it differ from that in developed world?
| Autor: | Madeha Awad, Sherif Abouelnaga, Amal Refaat, Nada El-Khateeb, Sameera Ezzat, Mohamed S. Zaghloul, Hala Taha, Mohamed El-Beltagy, Mohamed Kamal |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Ependymoma Cancer Research Pediatrics medicine.medical_specialty Adolescent Population Astrocytoma Craniopharyngioma Middle East 03 medical and health sciences 0302 clinical medicine Epidemiology Humans Medicine Child education Developing Countries Medulloblastoma education.field_of_study Brain Neoplasms business.industry Astrocytic Tumor Developed Countries Infant Newborn Infant Neoplasms Germ Cell and Embryonal medicine.disease Pediatric cancer Socioeconomic Factors Neurology Oncology Child Preschool 030220 oncology & carcinogenesis Female Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Neuro-Oncology. 126:371-376 |
| ISSN: | 1573-7373 0167-594X |
| DOI: | 10.1007/s11060-015-1979-7 |
| Popis: | Central nervous system (CNS) tumors are the most frequent solid tumors in children and adolescents. The epidemiology of these tumors differs in areas of the world. However, very little data is available in the low/middle income countries (LMIC). The aim of this study is to describe the characteristics of primary childhood brain tumors treated at a leading LMIC pediatric cancer hospital and its difference from that in other countries. One thousand one hundred fourteen children and adolescent having CNS tumors were treated in the largest pediatric cancer hospital in the Middle East during a period of 5½ years. They were diagnosed histopathologically in 80.2 %, through medical imaging in 19.4 % and via both tumor markers and imaging in the remaining 0.4 % of cases. Through epidemiological analysis was performed using all available patients' data revealed that 96 % of the patients had primary brain tumors, while only 4 % the primary lesion was in the spinal cord. The most common histological type was astrocytic tumor (30.0 %, pilocytic (GI) = 13.2 %, GII = 10.5 % and GIII + IV (high grade) = 6.3 %) followed by embryonal tumor (23.2 %, medulloblastoma = 18.7 %, PNET = 2.8 %, ATRT = 1.5 % and ependymoblastoma = 0.2 %) then ependymoma in 8.7 %, craniopharyngeoma in 5.3 %. The mean age at diagnosis was 7.1 ± 4.2 years which did not differ significantly by gender nor residency but it differed by the pathological subtype. The frequency of each pathological type was different among different age groups. Though the present study was a hospital-based analysis in a low/middle income country, yet it did not differ from the well-established population-based study reports in the high income countries. |
| Databáze: | OpenAIRE |
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