| Autor: |
Yuan Fang, Weiren Liu, Zheng Tang, Xiang Ji, Yufu Zhou, Shushu Song, Mengxin Tian, Chenyang Tao, Run Huang, Guiqi Zhu, Xifei Jiang, Jun Gao, Weifeng Qu, Han Wang, Peiyun Zhou, Xiaoling Wu, Lei Jin, Haixiang Sun, Zhenbin Ding, Yuanfei Peng, Shimin Zhao, Jian Zhou, Jia Fan, Wei Xu, Yinghong Shi |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Hepatology (Baltimore, Md.)REFERENCES. |
| ISSN: |
1527-3350 |
| Popis: |
Monocarboxylate transporter (MCT) 4 is a high-affinity lactate transporter that is primarily involved in the maintenance of intracellular pH homeostasis and highly expressed in different tumors. However, the role of MCT4 in modulating immune responses against HCC remains unknown.In this study, we demonstrated that MCT4 was overexpressed in HCC, which was associated with poor prognosis in patients. Genetic or pharmacological inhibition of MCT4 using VB124 (a highly potent MCT4 inhibitor) suppressed HCC tumor growth in immunocompetent mice model by enhancing CD8Our results revealed that lactate exportation by MCT4 has a tumor-intrinsic function in generating an immunosuppressive HCC environment and demonstrated the proof of the concept of targeting MCT4 in tailoring HCC immunotherapeutic approaches. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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