Development of novel lipidated analogs of picroside as vaccine adjuvants: Acylated analogs of picroside-II elicit strong Th1 and Th2 response to ovalbumin in mice
| Autor: | Tabasum Sidiq, Parvinder Pal Singh, Naresh Kumar Satti, Amit Gupta, Fayaz Malik, Gulam Nabi Qazi, Naveed A. Qazi, Anamika Khajuria, Jada Srinivas, K. A. Suri, H. M. Sampath Kumar |
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| Rok vydání: | 2010 |
| Předmět: |
CD4-Positive T-Lymphocytes
Male Interleukin 2 Ovalbumin Acylation Iridoid Glucosides CD8-Positive T-Lymphocytes Biology Pharmacology Immunoadjuvant Interferon-gamma Mice Th2 Cells Immune system Antigen medicine Animals Neutralizing antibody Interleukin 4 Cell Proliferation Mice Inbred BALB C General Veterinary General Immunology and Microbiology Vaccination Public Health Environmental and Occupational Health Th1 Cells Antibodies Neutralizing Molecular biology Titer Infectious Diseases Cinnamates Immunoglobulin G biology.protein Interleukin-2 Molecular Medicine Interleukin-4 medicine.drug |
| Zdroj: | Vaccine. 28:8327-8337 |
| ISSN: | 0264-410X |
| Popis: | The acylated analogs of picroside-II were synthesized and tested for immune-adjuvant activity in the presence of weak antigen ovalbumin found to stimulate anti-OVA IgG titer, neutralizing antibody (IgG1 and IgG2a) titer as well as the production of soluble mediators of a Th1 response (IL-2 and IFN-γ) and Th2 response (IL-4) and proliferation of T lymphocytes sub-sets (CD4/CD8). Furthermore, these modified analogs of picroside-II were able to elicit a substantial increase in anti-OVA IgG when compared with OVA alone. These results support the use of acylated analogs particularly PK-II-3 and PK-II-4 as potent enhancer of antigen-specific Th1 and Th2 immune responses and thus are promising immune-adjuvant candidate for vaccines. |
| Databáze: | OpenAIRE |
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