T2 heterogeneity as an in vivo marker of microstructural integrity in medial temporal lobe subfields in ageing and mild cognitive impairment
| Autor: | Hanna K. Isotalus, Christopher R. Madan, Volkan Nurdal, Alfie Wearn, Risto A. Kauppinen, Elizabeth Coulthard, Esther Saunders-Jennings, Sean-James Fallon, Michael J. Knight |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
T2 relaxometry Aging Neuropsychological Tests 0302 clinical medicine Cognition magnetic resonance imaging Beacon - Precision Imaging Cognitive decline Aged 80 and over 05 social sciences Neurodegeneration Middle Aged Alzheimer's disease Early diagnosis Magnetic Resonance Imaging Hippocampal subfields Temporal Lobe medial temporal lobe T2 heterogeneity Neurology Medial temporal lobe Female RC321-571 early diagnosis Cognitive Neuroscience Neurosciences. Biological psychiatry. Neuropsychiatry 050105 experimental psychology Article Temporal lobe 03 medical and health sciences Atrophy Alzheimer Disease medicine Humans 0501 psychology and cognitive sciences Cognitive Dysfunction Aged business.industry Mechanism (biology) Dentate gyrus medicine.disease Entorhinal cortex hippocampal subfields Ageing ageing business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Wearn, A R, Nurdal, V, Saunders-Jennings, E, Knight, M J, Madan, C R, Fallon, S-J, Isotalus, H K, Kauppinen, R A & Coulthard, E J 2021, ' T2 heterogeneity as an in vivo marker of microstructural integrity in medial temporal lobe subfields in ageing and mild cognitive impairment ', NeuroImage, vol. 238, 118214 . https://doi.org/10.1016/j.neuroimage.2021.118214 Neuroimage NeuroImage, Vol 238, Iss, Pp 118214-(2021) |
| ISSN: | 1053-8119 |
| Popis: | A better understanding of early brain changes that precede loss of independence in diseases like Alzheimer's disease (AD) is critical for development of disease-modifying therapies. Quantitative MRI, such as T2 relaxometry, can identify microstructural changes relevant to early stages of pathology. Recent evidence suggests heterogeneity of T2 may be a more informative MRI measure of early pathology than absolute T2. Here we test whether T2 markers of brain integrity precede the volume changes we know are present in established AD and whether such changes are most marked in medial temporal lobe (MTL) subfields known to be most affected early in AD. We show that T2 heterogeneity was greater in people with mild cognitive impairment (MCI; n = 49) compared to healthy older controls (n = 99) in all MTL subfields, but this increase was greatest in MTL cortices, and smallest in dentate gyrus. This reflects the spatio-temporal progression of neurodegeneration in AD. T2 heterogeneity in CA1-3 and entorhinal cortex and volume of entorhinal cortex showed some ability to predict cognitive decline, where absolute T2 could not, however further studies are required to verify this result. Increases in T2 heterogeneity in MTL cortices may reflect localised pathological change and may present as one of the earliest detectible brain changes prior to atrophy. Finally, we describe a mechanism by which memory, as measured by accuracy and reaction time on a paired associate learning task, deteriorates with age. Age-related memory deficits were explained in part by lower subfield volumes, which in turn were directly associated with greater T2 heterogeneity. We propose that tissue with high T2 heterogeneity represents extant tissue at risk of permanent damage but with the potential for therapeutic rescue. This has implications for early detection of neurodegenerative diseases and the study of brain-behaviour relationships. |
| Databáze: | OpenAIRE |
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