True hyponatremia in the setting of pegasparagase-induced hypertriglyceridemia: A case report

Autor:	Lily Olayinka, Izmarie Poventud-Fuentes, Shajia Rahman Ansari, Emily Garnett, Sridevi Devaraj
Rok vydání:	2022
Předmět:	Hypertriglyceridemia Biochemistry (medical) Clinical Biochemistry Asparaginase Humans Antineoplastic Agents General Medicine Precursor Cell Lymphoblastic Leukemia-Lymphoma Child Biochemistry Hyponatremia Polyethylene Glycols
Zdroj:	Clinica chimica acta; international journal of clinical chemistry. 531
ISSN:	1873-3492
Popis:	Pegasparagase (PEG-Asparaginase) induced hypertriglyceridemia is rare in the treatment of lymphoblastic lymphoma in children. We present a case of PEG-asparaginase induced hypertriglyceridemia that was incidentally identified and suspicion of its interference with sodium measurement in the clinical laboratory. The use of a direct ion selective method clarified the presence of true hyponatremia. The patient was treated with an oral Fenofibrate therapy which resolved the hypertriglyceridemia. This case highlights that PEG-asparaginanse and Olazanpine can induce hypertriglyceridemia in acute lymphoblastic leukemia and it may be useful to obtain baseline triglyceride measurements for these patients.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32c94185d8de5eb56710b2a921bba32c https://pubmed.ncbi.nlm.nih.gov/35283095 Zobrazit plný text záznamu Full Text from ScienceDirect