Lactobacillus plantarum P17630 for preventing Candida vaginitis recurrence: a retrospective comparative study
| Autor: | Andrea Sartore, Guglielmo Stabile, Gianpaolo Maso, D. De Santo, Fabio Parazzini, Stefano Restaino, Stefania Inglese, R. De Leo, M. Tonon, R. Banco, F. De Seta |
|---|---|
| Přispěvatelé: | DE SETA, Francesco, Parazzini, F, DE LEO, Rossella, Banco, Rubina, Maso, Gp, De Santo, D, Sartore, Andrea, Stabile, Guglielmo, Inglese, Stefania, Tonon, Maddalena, Restaino, Stefano |
| Rok vydání: | 2014 |
| Předmět: |
Adult
medicine.medical_specialty Antifungal Agents Adolescent Probiotic Gastroenterology law.invention Lactobacillus plantarum P17630 Young Adult law Recurrence Internal medicine Lactobacillus medicine Secondary Prevention Vulvovaginal candidiasis Humans Clotrimazole Adverse effect Candida albicans Candidiasis Vulvovaginal Retrospective Studies biology business.industry Microbiota Probiotics Obstetrics and Gynecology Middle Aged biology.organism_classification Corpus albicans Discontinuation Administration Intravaginal Reproductive Medicine Immunology Vagina Vaginal Creams Foams and Jellies Female business Lactobacillus plantarum medicine.drug |
| Zdroj: | European journal of obstetrics, gynecology, and reproductive biology. 182 |
| ISSN: | 1872-7654 |
| Popis: | BACKGROUND: Recurrence is a frequent complaint of patients with vulvovaginal candidiasis (VVC). Although the pathogenesis of VVC remains a controversial issue, disruption of the balance between the vaginal microbiota may facilitate overgrowth by Candida. Some probiotic bacterial strains can suppress Candida albicans; Lactobacillus plantarum P17630 is able to attach to vaginal epithelial cells and significantly reduce the adhesion of C. albicans. OBJECTIVE: To evaluate the effect of the application of Lactobacillus plantarum P17630 in restoring the vaginal microbiota and prevention of relapses among women with acute VVC undergoing conventional (azole) local and main therapy. METHODS: Retrospective comparative study. We recruited 89 women with a diagnosis of VVC, who were placed into two groups on the basis of reported treatment. The control group was treated with a daily dose of 2% clotrimazole vaginal cream at bedtime for 3 days, followed by vaginal application of a capsule containing lubricant once a day for 6 days and then once a week for another 4 weeks. The probiotic group was treated with the same azole-based protocol but followed by vaginal application of a capsule containing Lactobacillus plantarum P17630 (>10₈ CFU) once a day for 6 days and then once a week for another 4 weeks beginning the day following clotrimazole discontinuation. Clinical and diagnostic patterns were monitored for three months of follow-up. RESULTS: At the end of study the probiotic-treated women showed a statistically significant increase in Lactobacillus values "+++" (80% versus 40%, p5. CONCLUSION: Although the results of different studies are controversial, most have suggested use of probiotics in the prevention or treatment of VVC, and no adverse effects have been reported. Our data with L. plantarum P17630 (Gyno-Canesflor - Bayer) confirm the role of this specific strain as a potential empirical preventive agent for reducing vaginal discomfort after conventional treatment of acute VVC and shifting the vaginal milieu toward a predominance of lactobacilli with an improvement of the vaginal pH value. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect