Uterine choriocarcinoma diagnosed 11 years after menopause: A case report
| Autor: | Alaa Balaghi, Noha Bejjani, Michel Samaha, Richard Assaker, Kamal Tarabine, Georges El Hasbani, Hadi Ghanem, Bassel Abouzeid |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class medicine.medical_treatment Uterus lcsh:Surgery lcsh:Gynecology and obstetrics 03 medical and health sciences 0302 clinical medicine Medicine reproductive and urinary physiology lcsh:RG1-991 Gynecology Chemotherapy Pregnancy 030219 obstetrics & reproductive medicine medicine.diagnostic_test biology business.industry Choriocarcinoma Obstetrics and Gynecology lcsh:RD1-811 medicine.disease female genital diseases and pregnancy complications Menopause medicine.anatomical_structure 030220 oncology & carcinogenesis Ki-67 embryonic structures biology.protein Gonadotropin business Endometrial biopsy |
| Zdroj: | Case Reports in Women's Health, Vol 20, Iss, Pp-(2018) |
| ISSN: | 2214-9112 |
| Popis: | Background: Gestational trophoblastic neoplasms (GTNs) encompass a wide spectrum of diseases, of which choriocarcinoma is one of the most common. Choriocarcinoma occurs mainly in relation to pregnancy and rarely after the menopause. It has the potential to metastasize to organs other than the uterus. Case Report: We describe a 62-year-old woman who presented with postmenopausal bleeding 11 years after the menopause. Pelvic ultrasound and abdominal/pelvic computerized tomography showed an intrauterine mass. Choriocarcinoma was diagnosed by Pipelle endometrial biopsy with positive staining for beta-human chorionic gonadotropin (hCG) and KI 67 along with an elevated serum beta-hCG level. The tumor was managed with multiple cycles of multidrug chemotherapy and follow-up based on serum beta-hCG levels according to the guidelines of the International Federation of Gynecology and Obstetrics (FIGO). Conclusion: This case report highlights that choriocarcinoma, a tumor normally associated with pregnancy, can present after the menopause. Keywords: Postmenopausal Bleeding, Gestational Trophoblastic Neoplasms, Uterine Choriocarcinoma, Menopause, Chemotherapy |
| Databáze: | OpenAIRE |
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