The pyrethroid insecticide permethrin confers hepatotoxicity through DNA damage and mitochondria‐associated apoptosis induction in rat: Palliative benefits of Fumaria officinalis
| Autor: | Nissaf Aoiadni, Nour Chiab, Hajer Jdidi, Radhia Gargouri Bouzid, Abdelfattah El Feki, Hamadi Fetoui, Fatma Ghorbel Koubaa |
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| Rok vydání: | 2022 |
| Předmět: |
Male
Insecticides Health Toxicology and Mutagenesis Phytochemicals Apoptosis Toxicology Biochemistry Antioxidants Animals Proanthocyanidins Rats Wistar Pyruvates Molecular Biology Permethrin Transaminases Adenosine Triphosphatases Flavonoids Mammals Plant Extracts Fumaria Polyphenols General Medicine Mitochondria Rats Oxidative Stress C-Reactive Protein Liver Lactates Molecular Medicine Quercetin Chemical and Drug Induced Liver Injury DNA Damage |
| Zdroj: | Journal of Biochemical and Molecular Toxicology. 36 |
| ISSN: | 1099-0461 1095-6670 |
| Popis: | Permethrin (PER) is a pyrethroid pesticide that is extensively used as an insecticide in world because of its high activity and its low mammalian toxicity. The current study was conducted to investigate the protective action of Fumaria officinalis against PER-induced liver injury in male rats. However, HPLC-DAD showed the richness of 6 components in F. officinalis (F) including quercetin, ferulic acid, and naringenin which were the most abundant. Total polyphenols, total flavonoids, and condensed tannins were studied by phytochemical screening. In vitro, antioxidant properties showed that F. officinalis exhibited the highest DPPH radical, FRAP, and H |
| Databáze: | OpenAIRE |
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