Optic nerve sheath meningiomas
| Autor: | R A Nugent, Leo Koornneef, Valerie A. White, Jack Rootman, Peerooz Saeed, Ian R. A. Mackenzie |
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| Přispěvatelé: | CCA -Cancer Center Amsterdam, Other Research, Ophthalmology |
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male medicine.medical_specialty Visual acuity Adolescent genetic structures Nerve Sheath Neoplasms Diagnosis Differential Meningioma Age Distribution Atrophy Meningeal Neoplasms Humans Medicine Cranial nerve disease Sex Distribution Child Papilledema Aged Retrospective Studies business.industry Optic Nerve Neoplasms Middle Aged medicine.disease Magnetic Resonance Imaging eye diseases Surgery Optic nerve sheath meningioma Ophthalmology medicine.anatomical_structure Optic nerve Female medicine.symptom Tomography X-Ray Computed business Orbit (anatomy) |
| Zdroj: | Ophthalmology, 110(10), 2019-2030. Elsevier Inc. |
| ISSN: | 0161-6420 |
| DOI: | 10.1016/s0161-6420(03)00787-5 |
| Popis: | Purpose To study the natural history and growth of optic nerve sheath meningiomas and evaluate their management outcome. Design Clinicopathologic retrospective noncomparative case series. Methods A retrospective study of 88 patients who were treated between 1976 and 1999 at the University of British Columbia and the University of Amsterdam. Clinical reports, imaging studies, and histopathologic findings were reviewed. Results The mean age at onset of symptoms was 40.3 years, and most were seen in middle-aged females. Patients typically presented with visual loss, frequently associated with optic atrophy or papilledema and occasionally optociliary shunt vessels. On imaging, the optic nerve demonstrated segmental or diffuse thickening of the sheath or globular growth. Calcification was seen in 31% of cases and was associated with slower tumor growth. Tumors with posterior components in the orbit had more frequent intracranial involvement. Intracranial extension was more frequent and had a greater growth rate in younger patients. Irregular margins in the orbit implied local invasion. A presenting visual acuity better than 20/50 correlated with longer preservation of vision. Patients who underwent radiotherapy showed improvement in their visual acuity, and tumor growth was halted. Optic sheath decompression did not preserve vision. En bloc tumor excision was associated with no detectable recurrence in contrast to debulked tumors that recurred. Conclusions Meningiomas show characteristic indolent growth. Management therefore should be conservative in most cases. Radiotherapy is indicated in patients with progressive visual deterioration. Surgery, when indicated, should be an en bloc excision. |
| Databáze: | OpenAIRE |
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