Synthesis and function of amphiphilic glucan dendrimers as nanocarriers for protein delivery

Autor:	Shin-ichi Sawada, Kazunari Akiyoshi, Tomoki Nishimura, Akiko Kubo, Shigeo Takeda, Michiyo Yanase, Yoshihiro Sasaki, Kaori Umezaki
Rok vydání:	2019
Předmět:	Dendrimers Fluorescence assay Biomedical Engineering 02 engineering and technology 010402 general chemistry 01 natural sciences Surface-Active Agents Dendrimer Amphiphile Humans General Materials Science Particle Size Glucans Glucan chemistry.chemical_classification Drug Carriers Chemistry Enzymatic synthesis beta-Galactosidase 021001 nanoscience & nanotechnology Combinatorial chemistry Endocytosis 0104 chemical sciences Molecular Weight Nanoparticles Nanocarriers 0210 nano-technology Function (biology) HeLa Cells
Zdroj:	Biomaterials Science. 7:1617-1622
ISSN:	2047-4849 2047-4830
Popis:	We report the combined enzymatic synthesis of five glucan dendrimers with control of molecular weight and particle size. Amphiphilic properties were introduced through dodecyl group substitution. A Tokyo-green fluorescence assay showed that amphiphilic glucan dendrimers were able to successfully deliver active β-galactosidase to cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32c55e54b545af308a264832670bba12 https://doi.org/10.1039/c8bm01627e Zobrazit plný text záznamu