Nonalcoholic steatohepatitis in morbid obese patients: coffee consumption vs. disease severity
| Autor: | Luiz Antonio Rodrigues de Freitas, Erivaldo Alves, Raffaelle K. Barros, Carla Daltro, Claudia Daltro, Helma Pinchemel Cotrim, Yanaihara A Oliveira |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult Liver Cirrhosis Male medicine.medical_specialty Biopsy Bariatric Surgery Specialties of internal medicine Gastroenterology Severity of Illness Index Coffee Body Mass Index 03 medical and health sciences Liver disease 0302 clinical medicine Insulin resistance Non-alcoholic Fatty Liver Disease Risk Factors Statistical significance Internal medicine Surveys and Questionnaires NAFLD Nonalcoholic fatty liver disease Medicine Humans Hepatology medicine.diagnostic_test business.industry NASH General Medicine Hepatitis C Middle Aged Protective Factors medicine.disease Obesity Surgery Obesity Morbid 030104 developmental biology Cross-Sectional Studies Liver RC581-951 Liver biopsy 030211 gastroenterology & hepatology Female business Body mass index |
| Zdroj: | Annals of Hepatology, Vol 15, Iss 3, Pp 350-355 (2016) |
| ISSN: | 1665-2681 |
| Popis: | Introduction. Obesity correlates with nonalcoholic fatty liver disease (NAFLD) and occurs in 90 to 100% of severely obese individuals (body mass index [BMI] > 35 kg/m2). Coffee consumption (CC) has been associated with reduced progression of fibrosis in both hepatitis C infection and NAFLD; however, this topic is still under discussion when this liver disease affects severely obese individuals. Objective. To assess the association between CC, insulin resistance (IR) and histological NAFLD morbid obese patients. Material and methods. Cross-sectional study, including obese individuals undergoing bariatric surgery, liver biopsy and histological diagnosis between September 2013 and August 2014. The patients were classified into 3 groups according to their weekly CC: 0- 239.9 mL; 240-2099.9 mL and ≥ 2100 mL. Results. A total of 112 obese individuals were included (BMI = 41.9 ± 4.3 kg/m2), with a mean age of 34.7 ± 7.4 years; 68.6% were women. CC was reported by 72.3% of patients. There were no statistical significant differences between groups regarding the presence of IR (84.8% vs. 74.2% vs. 75.9%; p = 0.536). Progressively higher percentages of individuals with normal liver histology were observed (14.7% vs. 21.9% vs. 24.3%). NASH (65.7% vs. 70.3% vs. 57.5%) were observed among those who consumed greater coffee volumes (p = 0.812). In conclusion, obese individuals with elevated CC exhibited lower frequencies of NASH, although with no statistical significance in this sample. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|