Factors associated with a persistent delirium in the intensive care unit: A retrospective cohort study
| Autor: | Mark van den Boogaard, Arjen J. C. Slooter, Rens Kooken, Monica Pop-Purceleanu, Maarten van den Berg |
|---|---|
| Přispěvatelé: | Neuroprotection & Neuromodulation, Clinical sciences, Neurology |
| Rok vydání: | 2021 |
| Předmět: |
Adult
medicine.medical_specialty Referral Critical Care and Intensive Care Medicine Logistic regression Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18] law.invention All institutes and research themes of the Radboud University Medical Center length of stay law mental disorders medicine Humans risk factors Prospective Studies Retrospective Studies business.industry Mortality rate Other Research Radboud Institute for Health Sciences [Radboudumc 0] Delirium Retrospective cohort study Odds ratio Delirium/epidemiology Intensive care unit Confidence interval Intensive Care Units Emergency medicine medicine.symptom business |
| Zdroj: | Journal of Critical Care, 66, 132-137 Journal of Critical Care, 66, pp. 132-137 |
| ISSN: | 0883-9441 |
| Popis: | Purpose To explore differences between ICU patients with persistent delirium (PD), non-persistent delirium (NPD) and no delirium (ND), and to determine factors associated with PD. Materials and methods Retrospective cohort study including all ICU adults admitted for ≥12 h (January 2015–February 2020), assessable for delirium and followed during their entire hospitalization. PD was defined as ≥14 days of delirium. Factors associated with PD were determined using multivariable logistic regression analysis. Results Out of 10,295 patients, 3138 (30.5%) had delirium, and 284 (2.8%) had PD. As compared to NPD (n = 2854, 27.7%) and ND (n = 7157, 69.5%), PD patients were older, sicker, more physically restrained, longer comatose and mechanically ventilated, had a longer ICU and hospital stay, more ICU readmissions and a higher mortality rate. Factors associated with PD were age (adjusted odds ratio [aOR] 1.03; 95% confidence interval [CI] 1.02–1.04); emergency surgical (aOR 1.84; 95%CI 1.26–2.68) and medical (aOR 1.57; 95%CI 1.12–2.21) referral, mean Sequential Organ Failure Assessment (SOFA) score before delirium onset (aOR 1.18; 95%CI 1.13–1.24) and use of physical restraints (aOR 5.02; 95%CI 3.09–8.15). Conclusions Patients with persistent delirium differ in several characteristics and had worse short-term outcomes. Physical restraints were the most strongly associated with PD. |
| Databáze: | OpenAIRE |
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