Genetic and Clinical Predictors of Left Atrial Thrombus: A Single Center Case-Control Study
| Autor: | Paulus Kirchhof, Renate B. Schnabel, Adrian Springer, Ruben Schleberger, Marc D Lemoine, Florian Langer, Boris A. Hoffmann, Stephan Willems, Florian Oyen, Reinhard Schneppenheim, Christian Meyer |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
genetic association studies Original Manuscript 030204 cardiovascular system & hematology Single Center Risk Assessment 03 medical and health sciences 0302 clinical medicine Von Willebrand factor Left atrial Internal medicine Atrial Fibrillation medicine Diseases of the circulatory (Cardiovascular) system Humans echocardiography In patient 030212 general & internal medicine Thrombus Left atrial thrombus left atrial thrombus Aged biology business.industry transesophageal echocardiography Case-control study biomarkers Atrial fibrillation Thrombosis Hematology General Medicine medicine.disease von willebrand factor RC666-701 Case-Control Studies Cardiology biology.protein business Echocardiography Transesophageal |
| Zdroj: | Clinical and Applied Thrombosis/Hemostasis Clinical and Applied Thrombosis/Hemostasis, Vol 27 (2021) |
| ISSN: | 1938-2723 |
| Popis: | Left atrial (LA) thrombus formation is the presumed origin of thromboembolic complications in patients with atrial fibrillation (AF). Beyond clinical risk factors, the factors causing formation of LA thrombi are not well known. In this case-control study, we analyzed clinical characteristics and genetic thrombophilia markers (factor V Leiden (FVL), prothrombin G20210A (FIIV), Tyr2561 variant of von Willebrand factor (VWF-V)) in 42 patients with AF and LA thrombus (LAT) and in 68 control patients with AF without LAT (CTR). Patients with LAT had more clinical conditions predisposing to stroke (mean CHA2DS2-VASc-score 3.4 ± 1.5 vs. 1.9 ± 1.4; P < 0.001), a higher LA volume (96 ± 32 vs. 76 ± 21 ml, P = 0.002) and lower LA appendage emptying velocity (0.21 ± 0.11vs. 0.43 ± 0.19 m/s, P < 0.001). Prevalence of FVL, FIIV and VWF-V mutations was not different, but in the subgroup of patients |
| Databáze: | OpenAIRE |
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