Reversible severe ovarian enlargement in an infant with significant insulin resistance
| Autor: | Geffner Mitchell E, Giuffre Danielle, Lai Lillian, Cheung Clement, Ryabets-Lienhard Anna, Mikhchi Amir |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Rabson-Mendenhall
medicine.medical_specialty endocrine system Genetic syndromes medicine.medical_treatment Donohue R895-920 030218 nuclear medicine & medical imaging Muscle hypertrophy 03 medical and health sciences Medical physics. Medical radiology. Nuclear medicine 0302 clinical medicine Insulin resistance Internal medicine medicine Hyperinsulinemia Radiology Nuclear Medicine and imaging Ovarian enlargement Pediatric Enlargement business.industry Insulin medicine.disease Pathophysiology Endocrinology Ovarian Severe course business 030217 neurology & neurosurgery |
| Zdroj: | Radiology Case Reports, Vol 16, Iss 7, Pp 1760-1765 (2021) Radiology Case Reports |
| ISSN: | 1930-0433 |
| Popis: | The extent, severity, and radiological findings of ovarian growth in infants with genetic syndromes of insulin resistance have not been fully described. We report a rare case of reversible massive ovarian enlargement in a female infant with a congenital insulin resistance syndrome, likely Rabson-Mendenhall syndrome given the less clinically severe course. The patient presented with neonatal diabetes with hyperinsulinemia and hyperglycemia due to congenital insulin resistance. She developed increasing severe bilateral ovarian enlargement which peaked at 4 months of age, followed by gradual decrease in size of the ovaries following treatment with insulin-sensitizing drugs and improved hyperinsulinemia. The ovarian enlargement is postulated to be secondary to the trophic effects of insulin acting in a gonadotropin-independent mechanism. Hyperinsulinemia in congenital insulin resistance can also result in hypertrophy of other organs. Understanding the pathophysiology behind massive ovarian enlargement in the setting of congenital insulin resistance syndromes can help guide appropriate therapy. |
| Databáze: | OpenAIRE |
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