The prognosis of fixed dystonia: a follow-up study
| Autor: | Davide Martino, Richard J. Brown, Michael R. Trimble, B.P.C. van de Warrenburg, Anette Schrag, Kailash P. Bhatia, Norlinah Mohamed Ibrahim, Niall Quinn |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.drug_class Dissociative Young Adult Surveys and Questionnaires Internal medicine medicine Perception and Action [DCN 1] Humans Corticobasal degeneration Psychogenic dystonia Depression (differential diagnoses) Aged Aged 80 and over Dystonia Follow up studies Middle Aged Prognosis medicine.disease Treatment Outcome Complex regional pain syndrome Neurology Dystonic Disorders Physical therapy Anxiety Female Neurology (clinical) Geriatrics and Gerontology medicine.symptom Psychology Follow-Up Studies |
| Zdroj: | Parkinsonism & Related Disorders, 15, 8, pp. 592-7 Parkinsonism & Related Disorders, 15, 592-7 |
| ISSN: | 1353-8020 |
| Popis: | Contains fulltext : 81193.pdf (Publisher’s version ) (Closed access) BACKGROUND: The syndrome of fixed dystonia includes both CRPS-dystonia and psychogenic dystonia. The underlying mechanisms are unclear, but a high prevalence of neuropsychiatric illness has previously been reported. METHODS: Clinical and neuropsychiatric follow-up study by telephone and self-administered instruments (HADS, SDQ-20, DES II, EQ-5D), on 41 patients with fixed dystonia after a mean of 7.6 (+/-3.6) years. RESULTS: We obtained information on clinical outcome in 35 (85.4%) patients and neuropsychiatric questionnaire data in 22 (53.7%). Eighty-three percent were women. Thirty-one percent had worsened, 46% were the same and 23% had improved, of whom 6% had major remissions. At follow-up, mean duration of illness was 11.8 (+/-4.9) years and mean age 43.2 (+/-14.8) years. Except for 1 patient who was re-diagnosed with corticobasal degeneration, the diagnosis remained unchanged in others. Forty-one percent had scores indicating anxiety and 18% indicating depression; 18% scored within the range of dissociative/somatoform disorders on DES II and 19% on SDQ-20. The mean EQ-5D index and VAS scores were 0.34 and 56.1%. Comparison between the 3 outcome groups revealed significant difference only in the EQ-5D (p=0.003). Only baseline CRPS predicted a worse outcome (chi(2)=0.006). CONCLUSIONS: Our findings revealed that the prognosis of this syndrome is poor, with improvement in less than 25% of patients, major remission in only 6% and continued worsening in a third. A high rate of neuropsychiatric findings was noted and new neuropsychiatric features had occurred in some. Average health status was poor. Of the baseline parameters, only CRPS predicted poorer outcome. |
| Databáze: | OpenAIRE |
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