Presence of 1,25-dihydroxyvitamin D3-glycoside in the calcinogenic plant Cestrum diurnum
| Autor: | M. R. Hughes, Toni A. McCain, Sai Y. Chang, Michael Villareale, Mark R. Haussler, Robert H. Wasserman |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Vitamin
medicine.medical_specialty Hypercalcaemia Chromatography Gas Receptors Drug chemistry.chemical_element Cestrum diurnum Calcium Mass Spectrometry chemistry.chemical_compound Internal medicine Botany medicine Ingestion Animals Glycosides chemistry.chemical_classification Multidisciplinary biology Hydroxycholecalciferols Glycoside biology.organism_classification medicine.disease Plants Toxic Endocrinology chemistry Dihydroxycholecalciferols Biological Assay Solanum Carrier Proteins Chickens Calcification |
| Zdroj: | Nature. 268(5618) |
| ISSN: | 0028-0836 |
| Popis: | A DISEASE clinically and morphologically similar to vitamin D-intoxication, characterised by hypercalcaemia and extensive soft tissue calcification, has been described in grazing animals and linked to the ingestion of leaves from several plant species including Cestrum diurnum (C.d.)1–3 and Solanum malacoxylon3. Early reports indicated that activity resembling the hormonal form of vitamin D3, 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3), existed in extracts of both of these plants3–5. The active calcitropic principle from S. malacoxylon has been identified as a 1,25-(OH)2D3-glycoside6–8. We report here the isolation and identification of a 1,25-(OH)2D3-glycoside in C.d. It is proposed that this principle accounts for the hyperabsorption of calcium found in animals eating this plant. |
| Databáze: | OpenAIRE |
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