Nicotine Aerosol Generation from Thermally Reversible Zinc Halide Complexes Using the Staccato® System
| Autor: | Ryan Timmons, Krishnamohan Sharma, Kathleen Simis, Ron L. Hale, Jim Cassella, Mingzu Lei, Amy Lu |
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| Rok vydání: | 2008 |
| Předmět: |
Aerosols
Bromides Pharmacology Nicotine Thermogravimetric analysis Calorimetry Differential Scanning Chemistry Nebulizers and Vaporizers Organic Chemistry Inorganic chemistry Pharmaceutical Science chemistry.chemical_element Halide Zinc Chloride Differential scanning calorimetry Chlorides Zinc Compounds Thermogravimetry Drug Discovery Vaporization medicine Particle size medicine.drug |
| Zdroj: | Drug Development and Industrial Pharmacy. 34:936-942 |
| ISSN: | 1520-5762 0363-9045 |
| Popis: | Application of the Staccato system to liquid drugs presents unique technological challenges. Liquids, such as nicotine, do not form physically stable films on vaporization substrates. We identified two thermally reversible zinc halides (ZnCl2 and ZnBr2) that complex with nicotine in a 1:2 mol ratio (zinc halide: nicotine) that can be coated as a solid film. Feasibility studies indicated that the chloride complex liberates a higher fraction of nicotine upon heating whereas the nicotine aerosol purity for both complexes was approximately 99%. Using a multidose Staccato device previously used in a Phase I clinical trial, we demonstrated that highly pure nicotine aerosol can be reliably generated from the chloride complex with the following qualities: aerosol purity approximately 99%, single emitted dose approximately 117 microg, particle fraction approximately 57%, and mean particle size approximately 0.8 microm. These results were supported by thermogravimetric analysis and differential scanning calorimetry. |
| Databáze: | OpenAIRE |
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