Microfilament-coordinated adhesion dynamics drives single cell migration and shapes whole tissues
| Autor: | Miguel Vicente-Manzanares, Carlos Vicente, Rocío Aguilar-Cuenca, Clara Llorente-Gonzalez |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
integrin Nuclear Structure & Function Integrin Morphogenesis Cell Growth & Division morphogenesis Review myosin Biology Microfilament migration General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Cell Adhesion clutch General Pharmacology Toxicology and Pharmaceutics Cell adhesion Actin Cytoskeleton General Immunology and Microbiology Cadherin Cell migration General Medicine Articles Actin cytoskeleton Developmental Molecular Mechanisms II Morphogenesis & Cell Biology adhesion 030104 developmental biology biology.protein Neuroscience actin Control of Gene Expression |
| Zdroj: | Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid Consejería de Sanidad de la Comunidad de Madrid F1000Research |
| Popis: | Cell adhesion to the substratum and/or other cells is a crucial step of cell migration. While essential in the case of solitary migrating cells (for example, immune cells), it becomes particularly important in collective cell migration, in which cells maintain contact with their neighbors while moving directionally. Adhesive coordination is paramount in physiological contexts (for example, during organogenesis) but also in pathology (for example, tumor metastasis). In this review, we address the need for a coordinated regulation of cell-cell and cell-matrix adhesions during collective cell migration. We emphasize the role of the actin cytoskeleton as an intracellular integrator of cadherin- and integrin-based adhesions and the emerging role of mechanics in the maintenance, reinforcement, and turnover of adhesive contacts. Recent advances in understanding the mechanical regulation of several components of cadherin and integrin adhesions allow us to revisit the adhesive clutch hypothesis that controls the degree of adhesive engagement during protrusion. Finally, we provide a brief overview of the major impact of these discoveries when using more physiological three-dimensional models of single and collective cell migration. |
| Databáze: | OpenAIRE |
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