Ten years of BSE surveillance in Italy: Neuropathological findings in clinically suspected cases
| Autor: | Barbara Iulini, Maria Domenica Pintore, Giorgio Palù, E. Vallino Costassa, Antonio D'Angelo, Cristiana Maurella, Cristina Casalone, C Porcario, D. Gelmetti, Cristiano Salata, D. Corbellini, Alessandra Pautasso, T. Avanzato, Maria Caramelli |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Male
Pathology medicine.medical_specialty Frontal cortex animal diseases Bovine spongiform encephalopathy Scrapie Neuropathology Disease Real-Time Polymerase Chain Reaction BSE Surveillance mental disorders medicine Animals Prion protein Atypical BSE General Veterinary Reverse Transcriptase Polymerase Chain Reaction business.industry food and beverages Brain Bovine medicine.disease Immunohistochemistry nervous system diseases Encephalopathy Bovine Spongiform Italy Population Surveillance Cattle Female Differential diagnosis business |
| Popis: | Between 2001 and 2010, 244 clinically suspected cases of bovine spongiform encephalopathy (BSE) were reported in Italy. This report summarizes the neuropathological findings in cattle displaying clinical signs consistent with a diagnosis of BSE. All animal specimens were submitted for confirmatory testing; samples testing negative underwent neuropathological examination to establish the differential diagnosis. Immunohistochemistry for scrapie prion protein (PrPSc) at the level of frontal cortex was carried out to exclude atypical BSE. Neuropathological changes were detected in 34.9% of cases; no histological lesions were found in 52.3% of subjects; 12.8% of samples were found unsuitable for analysis. BSE was detected in one case, but no cases of atypical BSE were observed. This study identified the diseases most commonly encountered in the differential diagnosis of BSE; furthermore, it demonstrated that the surveillance system is necessary for monitoring neuropathological disease in cattle and for the detection of BSE cases. |
| Databáze: | OpenAIRE |
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