Task-dependent Activity and Connectivity Predict Episodic Memory Network-based Responses to Brain Stimulation in Healthy Aging
| Autor: | Alvaro Pascual-Leone, Carles Falcon, Roser Sala-Llonch, Núria Bargalló, Isaias Mena-Sánchez, David Bartrés-Faz, Pablo Martin-Trias, Eider M. Arenaza-Urquijo, Imma C. Clemente, Didac Vidal-Piñeiro |
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| Rok vydání: | 2014 |
| Předmět: |
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Aging genetic structures Brain activity and meditation Memory Episodic medicine.medical_treatment Functional magnetic resonance imaging Biophysics Neuropsychological Tests behavioral disciplines and activities Article lcsh:RC321-571 medicine Humans Levels-of-processing effect lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Episodic memory Aged Aged 80 and over Brain Mapping Resting state fMRI medicine.diagnostic_test General Neuroscience Brain Level of processing Cognition Middle Aged Magnetic Resonance Imaging Transcranial Magnetic Stimulation Transcranial magnetic stimulation nervous system Brain stimulation Female Neurology (clinical) Nerve Net Psychology Neuroscience psychological phenomena and processes |
| Zdroj: | Brain Stimulation, Vol 7, Iss 2, Pp 287-296 (2014) |
| ISSN: | 1935-861X |
| Popis: | Background Transcranial magnetic stimulation (TMS) can affect episodic memory, one of the main cognitive hallmarks of aging, but the mechanisms of action remain unclear. Objectives To evaluate the behavioral and functional impact of excitatory TMS in a group of healthy elders. Methods We applied a paradigm of repetitive TMS – intermittent theta-burst stimulation – over left inferior frontal gyrus in healthy elders ( n = 24) and evaluated its impact on the performance of an episodic memory task with two levels of processing and the associated brain activity as captured by a pre and post fMRI scans. Results In the post-TMS fMRI we found TMS-related activity increases in left prefrontal and cerebellum-occipital areas specifically during deep encoding but not during shallow encoding or at rest. Furthermore, we found a task-dependent change in connectivity during the encoding task between cerebellum-occipital areas and the TMS-targeted left inferior frontal region. This connectivity change correlated with the TMS effects over brain networks. Conclusions The results suggest that the aged brain responds to brain stimulation in a state-dependent manner as engaged by different tasks components and that TMS effect is related to inter-individual connectivity changes measures. These findings reveal fundamental insights into brain network dynamics in aging and the capacity to probe them with combined behavioral and stimulation approaches. |
| Databáze: | OpenAIRE |
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