Impact of Dry Eye on Visual Acuity and Contrast Sensitivity: Dry Eye Assessment and Management Study
| Autor: | Gui-Shuang Ying, Meng C. Lin, Penny A. Asbell, Dry Eye Assessment, Maureen G. Maguire, Loretta B Szczotka-Flynn, Reza Dana, Vatinee Y Bunya |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Refractive error Visual acuity genetic structures Study research Visual Acuity Meibomian gland Eye Ophthalmology & Optometry Medical and Health Sciences 0302 clinical medicine Medicine Contrast (vision) Ocular Surface Disease Index Schirmer test media_common Meibomian Glands Middle Aged Dry Eye Assessment and Management (DREAM) Study Research Group Drug Combinations medicine.anatomical_structure Eicosapentaenoic Acid Dry Eye Syndromes Female medicine.symptom Adult medicine.medical_specialty Docosahexaenoic Acids media_common.quotation_subject Article Contrast Sensitivity 03 medical and health sciences Double-Blind Method Clinical Research Ophthalmology Humans Eye Disease and Disorders of Vision Aged business.industry medicine.disease eye diseases Cross-Sectional Studies Tears 030221 ophthalmology & optometry sense organs business 030217 neurology & neurosurgery Optometry Linear trend |
| Zdroj: | Optom Vis Sci Optometry and vision science : official publication of the American Academy of Optometry, vol 96, iss 6 |
| ISSN: | 1538-9235 1040-5488 |
| DOI: | 10.1097/opx.0000000000001387 |
| Popis: | Author(s): Szczotka-Flynn, Loretta B; Maguire, Maureen G; Ying, Gui-Shuang; Lin, Meng C; Bunya, Vatinee Y; Dana, Reza; Asbell, Penny A; Dry Eye Assessment and Management (DREAM) Study Research Group | Abstract: SIGNIFICANCE:Identification of the association of specific signs of dry eye disease with specific visual function deficits may allow for more targeted approaches to treatment. PURPOSE:The purpose of this study was to explore the association of dry eye signs and symptoms with visual acuity (VA) and contrast sensitivity in the Dry Eye Assessment and Management study. METHODS:Baseline data from participants in the Dry Eye Assessment and Management study were used in this secondary cross-sectional analysis. Standardized procedures were used to obtain results on the Ocular Surface Disease Index (OSDI), high-contrast logMAR VA, contrast sensitivity, tear film debris, tear breakup time (TBUT), corneal fluorescein staining, meibomian gland evaluation, conjunctival lissamine green staining, and Schirmer test scores. Generalized linear models that included age, refractive error status, and cataract status were used to assess the association between VA and contrast sensitivity with OSDI score and each dry eye sign. The Hochberg procedure was used to account for multiple comparisons. RESULTS:Among 487 participants (974 eyes), worse VA was associated with worse mean score on the OSDI vision subscale (39.4 for VA 20/32 or worse vs. 32.4 for VA 20/16 or better; adjusted linear trend, P = .02); scores were not associated with contrast sensitivity. Severe meibomian gland plugging and abnormal secretions were associated with worse mean log contrast sensitivity (1.48 for severe vs. 1.54 for not plugged [P = .04] and 1.49 for obstructed vs. 1.57 for clear [P = .002], respectively). Longer TBUT was associated with better mean log contrast sensitivity (1.57 for TBUT g5 seconds and 1.51 for TBUT ≤2 seconds, P l .0001). CONCLUSIONS:Worse VA rather than worse contrast sensitivity drives vision-related symptoms in dry eye. Greater tear film instability was associated with worse contrast sensitivity. |
| Databáze: | OpenAIRE |
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