Immune mediators associated to male infertility in a mouse model of DNA immunization with the sperm protease proacrosin

Autor: Mónica H. Vazquez-Levin, Maria Florencia Veiga, Romina Cecilia Russi, Carolina Veaute, María Inés García, Paulina Vignatti
Rok vydání: 2015
Předmět:
0301 basic medicine
Male
medicine.medical_treatment
Acrosome reaction
IMMUNOLOGY
Male infertility
Mice
0302 clinical medicine
ACROSIN
Pregnancy
Vaccines
DNA
Immunology and Allergy
Birth Rate
Acrosin
Enzyme Precursors
030219 obstetrics & reproductive medicine
biology
Obstetrics and Gynecology
Seminal Vesicles
Bioquímica y Biología Molecular
Cytokine
Cellular Microenvironment
GENE IMMUNIZATION
Cytokines
Female
Antibody
CIENCIAS NATURALES Y EXACTAS
Infertility
medicine.medical_specialty
Immunology
Immunization
Secondary
Mice
Inbred Strains
INFERTILITY
Ciencias Biológicas
Andrology
03 medical and health sciences
Immune system
Antigen
Internal medicine
medicine
Animals
SEMINAL VESICLE
Infertility
Male
CYTOKINES
medicine.disease
Sperm
030104 developmental biology
Endocrinology
Reproductive Medicine
Immunoglobulin G
biology.protein
Zdroj: Journal of reproductive immunology. 118
ISSN: 1872-7603
Popis: The immune response has relevant physiological functions both in the male and female reproductive system, and must be tightly controlled to achieve a successful pregnancy. Several immune factors have been related to infertility, among them humoral and cellular immune responses triggered by sperm antigens. The present study was aimed at evaluating the immune profile induced by DNA immunization against the sperm protease proacrosin in CF1 male mice and its effect upon fertility. Immunized animals exhibited higher anti-proacrosin antibodies levels than controls (indirect ELISA), both in serum (p
Databáze: OpenAIRE
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