Percentile curves of serum estradiol levels during controlled ovarian stimulation in 905 cycles stimulated with recombinant FSH show that high estradiol is not detrimental to IVF outcome
| Autor: | François Goffinet, Y. Janssens, Y. Fulla, Juliette Guibert, Theocharis C. Papageorgiou, Jean-René Zorn, Catherine Patrat |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
medicine.medical_specialty Percentile Pregnancy Rate medicine.drug_class medicine.medical_treatment Physiology Fertilization in Vitro Biology Chorionic Gonadotropin Drug Administration Schedule Follicle-stimulating hormone Ovulation Induction Pregnancy Internal medicine Statistical significance medicine Humans Estradiol Rehabilitation Obstetrics and Gynecology medicine.disease Hormones Recombinant Proteins Pregnancy rate Treatment Outcome Endocrinology Reproductive Medicine Estrogen Female Ovulation induction Follicle Stimulating Hormone Gonadotropin hormones hormone substitutes and hormone antagonists |
| Zdroj: | Human Reproduction. 17:2846-2850 |
| ISSN: | 1460-2350 0268-1161 |
| DOI: | 10.1093/humrep/17.11.2846 |
| Popis: | BACKGROUND: High, normal and poor responders are usually defined by reference to subjectively selected estradiol (E 2 ) levels at days 4-6 and the day of hCG administration (d-hCG). The purpose of this study was to use E 2 percentile curves from day 5 until d-hCG to determine high, normal and poor responders, and to predict IVF outcome. METHODS: In this retrospective study, 762 patients underwent 905 cycles with a GnRH agonist/ recombinant FSH short protocol. They were divided into three groups according to their age. Percentile E 2 curves according to E 2 levels were plotted. High responders were those patients with E 2 levels above the 90th percentile, normal responders had E 2 between the 10th and 90th percentiles, and poor responders had E 2 below the 10th percentile. RESULTS: IVF outcome, expressed as number of oocytes, total embryos obtained and number of high grade embryos, was significantly better for patients with E 2 above the 90th percentile at d-hCG for the three age groups and at day 5 for group A ( |
| Databáze: | OpenAIRE |
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