Repurposed Therapeutic Strategies towards COVID-19 Potential Targets Based on Genomics and Protein Structure Remodeling
| Autor: | Ankit Kumar Dubey, Aakansha Singh, Ashok Kumar Singh |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
0301 basic medicine
03 medical and health sciences 030104 developmental biology 0302 clinical medicine Protein structure Coronavirus disease 2019 (COVID-19) 030220 oncology & carcinogenesis InformationSystems_INFORMATIONSTORAGEANDRETRIEVAL Genomics Computational biology Biology GeneralLiterature_REFERENCE(e.g. dictionaries encyclopedias glossaries) |
| DOI: | 10.5772/intechopen.96728 |
| Popis: | Target recognition is important for the identification of drugs with a high target specificity and/or for the development of existing drugs that could be replicated for the treatment of SARS-CoV-2 infections. Since SARS-CoV-2 is a pathogen recently discovered, no specific medicines have been identified or are available at present. The scientific community had proposed list of current drugs with therapeutic potential for COVID-19 on the basis of genomic sequence information coupled with protein structure modeling, posing an effective and productive therapeutic approach for repurposing existing drugs. The possible therapeutics for the treatment of COVID-19 involves a wide range of alternatives, encompassing nucleic acid-based treatments directed at the expression of genes of viruses, cytokine therapy, genetic engineered and vectored antibodies, and different formulations of vaccines. The future prospective in the treatment approaches the exploration of antiviral therapy, such as screening of prevailing molecules or libraries, testing of existing broad-spectrum antiviral medications, modern drug discovery focused on genomic knowledge and biochemical properties of various coronaviruses to create new targeted drugs. |
| Databáze: | OpenAIRE |
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