Prognosis of men with high-risk prostate cancer stratified by risk factors: a population-based retrospective cohort study
| Autor: | Qiang Dong, Mengxuan Shu, Xiaoyu Di, Yuxin Qing, Pan Song, Yaxin Li, Jiaxiang Wang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Surveillance Epidemiology and End Results (SEER) business.industry Retrospective cohort study Population based medicine.disease Prostate cancer high-risk factors Internal medicine medicine Radiology Nuclear Medicine and imaging Original Article prognosis business Prostate cancer (PCa) |
| Zdroj: | Translational Cancer Research |
| ISSN: | 2219-6803 2218-676X |
| Popis: | Background The aim was to evaluate the prognosis of men with all possible high-risk prostate cancers (PCa) stratified by risk factors. Methods Within the Surveillance, Epidemiology and End Results (SEER) database from 2004 to 2015, men with non-metastasis high-risk PCa were identified. Kaplan-Meier analysis and Cox regressions were adopted to evaluate the overall survival (OS) and prostate cancer-specific survival (PCSS). Nomograms were conducted to build a predictive model. Concordance index (C-index) and calibration curves were used to validate the model. Results A total of 151,799 patients were included. Seven risk groups were divided including one high-risk factor of T3–4 (A1), prostate-specific antigen (PSA) >20 ng/mL (A2), and Gleason score (GS) 8–10, two high-risk factors of T3–4 PSA >20 ng/mL (B1), T3–4 GS 8–10 (B2), PSA >20 ng/mL GS 8–10 (B3), and three high-risk factors of T3–4 PSA >20 ng/mL GS 8–10 (C). The survival curves of PCSS showed that A1 was the best among all groups. A2, A3 and B1 had similar results and were all better than B2 [with A2 as reference, A3 hazard ratio (HR): 1.09 (1.02–1.17), P=0.046; B1 HR: 0.93 (0.82–1.05), P=0.103; B2 HR: 1.42 (1.32–1.53), P20 ng/mL and GS 8–10 had the worst PCSS among all patients. PCa with three high-risk factors was not more aggressive than that with two high-risk factors of GS 8–10 and PSA >20 ng/mL. |
| Databáze: | OpenAIRE |
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