Novel malonamide derivatives as potent κ opioid receptor agonists

Autor:	Michael Koblish, Minghua Gu, Thomas M. Graczyk, Patrick J. Little, Nathalie Conway-James, Robert N. DeHaven, Serge Belanger, Diane L. DeHaven-Hudkins, Guo-Hua Chu, Joel A. Cassel, Roland E. Dolle
Rok vydání:	2007
Předmět:	Agonist Stereochemistry medicine.drug_class Chemistry Pharmaceutical Clinical Biochemistry Analgesic Drug Evaluation Preclinical Molecular Conformation Pharmaceutical Science Biochemistry Chemical synthesis κ-opioid receptor Inhibitory Concentration 50 chemistry.chemical_compound Opioid receptor Amide Drug Discovery medicine Humans Molecular Biology Receptors Opioid kappa Organic Chemistry Malonates In vitro Kinetics Cytochrome P-450 CYP2D6 Models Chemical chemistry Opioid Drug Design Molecular Medicine medicine.drug
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 17:1951-1955
ISSN:	0960-894X
DOI:	10.1016/j.bmcl.2007.01.053
Popis:	A novel series of malonamide derivatives was synthesized. These amides were shown to be potent and selective kappa opioid receptor agonists.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32ad212de03125134561624676bd1165 https://doi.org/10.1016/j.bmcl.2007.01.053 Zobrazit plný text záznamu Full Text from ScienceDirect