Successful treatment of idiopathic recurrent pericarditis in children with interleukin-1β receptor antagonist (anakinra): An unrecognized autoinflammatory disease?
| Autor: | Giacomo Brisca, Francesco Traverso, Anna Loy, Alberto Martini, Paolo Picco, Marco Gattorno |
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| Rok vydání: | 2009 |
| Předmět: |
Male
musculoskeletal diseases medicine.medical_specialty Adolescent medicine.drug_class Interleukin-1beta Immunology Autoimmune Diseases Pericarditis Rheumatology Recurrence medicine Humans Immunology and Allergy Pharmacology (medical) Autoinflammatory disease Anakinra business.industry Receptors Interleukin-1 medicine.disease Receptor antagonist Dermatology Surgery Rilonacept Interleukin 1β Interleukin 1 Receptor Antagonist Protein Steroid therapy Antirheumatic Agents Female Recurrent pericarditis business Biomarkers medicine.drug |
| Zdroj: | Arthritis & Rheumatism. 60:264-268 |
| ISSN: | 1529-0131 0004-3591 |
| Popis: | Recurrent pericarditis occurs in association with various medical conditions, but in most cases the condition appears to be idiopathic. Although high-dose steroid treatment is often effective, it may have serious side effects. Herein we describe 3 children with recurrent pericarditis who were treated at our hospital, during flares, with the interleukin-1beta receptor antagonist anakinra, with immediate response. Pericarditis recurred when anakinra treatment was discontinued, and no further episodes occurred after it was resumed. Idiopathic recurrent pericarditis shares several features with autoinflammatory diseases, and anakinra has been efficacious in the treatment of the latter diseases. The findings in these patients suggest that idiopathic recurrent pericarditis may be a previously unrecognized autoinflammatory disease. |
| Databáze: | OpenAIRE |
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