Effects of neonatal focal cerebral hypoxia–ischemia on sleep–waking pattern, ECoG power spectra and locomotor activity in the adult rat
| Autor: | Serge Akoka, L. Pourcelot, Bei-Li Zhang, François Mailliet, Frederic Sannajust, Daniel Antier |
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| Rok vydání: | 1998 |
| Předmět: |
Male
medicine.medical_specialty Ischemia Motor Activity Central nervous system disease Internal medicine medicine Animals Circadian rhythm Rats Wistar Wakefulness Hypoxia Brain Molecular Biology Electrocorticography Slow-wave sleep medicine.diagnostic_test business.industry General Neuroscience Electroencephalography Hypoxia (medical) medicine.disease Magnetic Resonance Imaging Rats Electrophysiology Endocrinology Animals Newborn Ischemic Attack Transient Anesthesia Neurology (clinical) medicine.symptom Sleep business Developmental Biology |
| Zdroj: | Brain Research. 807:29-37 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/s0006-8993(98)00703-3 |
| Popis: | The aim of this study was to determine the influence of neonatal focal cerebral hypoxia-ischemia (HI) on sleep-waking pattern, electrocorticogram (ECoG) power spectra and locomotor activity (LA) in adult Wistar rats. Seven-day old pups were subjected to permanent unilateral ligation of the common carotid artery and transient hypoxia (8% O2). At 10 weeks of age, the extent of brain damages was evaluated by magnetic resonance imaging (MRI) and homogenous injured animals were selected before chronic implantation of radiotelemetry device. Using a single ECoG recording channel method, waking (W), paradoxical sleep (PS) and slow wave sleep (SWS) were continuously recorded for 72 h and they were semi-automatically analyzed off-line. We observed that neonatal HI triggers a cascade of events leading, in adult rats, to brain dysfunction characterized by an increase in SWS (55.0 vs. 40.2% in sham-operated rats, p |
| Databáze: | OpenAIRE |
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