Association of Appendicitis, Helicobacter Pylori Positive Gastritis and Thrombotic Thrombocytopenic Purpura in an Adolescent

Autor: Josipa Radić, Sandra Prgomet, Marijan Saraga, Tanja Kovačević, Zoltán Prohászka, Eugenija Marušić, Adela Arapović, Ranka Despot
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
medicine.medical_specialty
Adolescent
Thrombotic thrombocytopenic purpura
ADAMTS13 Protein
030204 cardiovascular system & hematology
Gastroenterology
Helicobacter Infections
03 medical and health sciences
0302 clinical medicine
Melena
hemic and lymphatic diseases
Internal medicine
medicine
Humans
Purpura
Autoantibodies
Thrombotic Thrombocytopenic
Purpura
Thrombotic Thrombocytopenic

biology
business.industry
BIOMEDICINE AND HEALTHCARE. Basic Medical Sciences
Articles
General Medicine
Microangiopathic hemolytic anemia
Helicobacter pylori
Appendicitis
biology.organism_classification
medicine.disease
ADAMTS13
Helicobacter Pylori
Platelet transfusion
Gastritis
030220 oncology & carcinogenesis
Fresh frozen plasma
medicine.symptom
BIOMEDICINA I ZDRAVSTVO. Temeljne medicinske znanosti
business
Zdroj: The American Journal of Case Reports
American Journal of Case Reports
Volume 20
ISSN: 1941-5923
Popis: Patient: Male, 16 Final Diagnosis: Thrombotic thrombocytopenic purpura Symptoms: Anemia Medication: — Clinical Procedure: — Specialty: Pediatrics and Neonatology Objective: Unusual clinical course Background: Thrombotic thrombocytopenic purpura (TTP) in children is a rare life-threatening syndrome, characterized by microangiopathic hemolytic anemia, thrombocytopenia with renal dysfunction, neurologic symptoms, and fever. TTP is usually caused by deficient activity of von Willebrand factor cleaving protease (ADAMTS13), due to either gene mutations or acquired via anti-ADAMTS13 autoantibodies. It can be triggered by bone marrow or solid organ transplantation, cardiothoracic-, abdominal-, and orthopedic surgeries, infections including very rarely Helicobacter pylori infection. Case Report: Here we report a case of a 16-year-old male with TTP, who presented with thrombocytopenia before an appendectomy. Seven days after surgery, our patient started to vomit, developed melena, and was admitted to our pediatric intensive care unit (PICU) with clinical presentation of shock. Gastroscopy revealed H. pylori positive hemorrhagic gastritis. The patient was treated by erythrocyte transfusions, fresh frozen plasma, human albumin, glucose-electrolyte solutions, vitamin K, platelet transfusion before implantation of central venous catheter, and antibiotics. After 36 hours, we started plasma exchange (PEX). Blood tests showed deficiency of ADAMTS13. Due to the presence of anti-ADAMTS13 autoantibodies, rituximab was administered. Due to generalized tonic-clonic seizures, he was artificially ventilated. Brain MR angiography showed small ischemic cerebro-vascular insult in the arteria cerebri media region. Despite immunosuppressive therapy and PEX, the patient did not improve completely until the H. pylori infection was eradicated. After which, he recovered completely. Conclusions: We present a rare case of TTP accompanied with appendicitis and gastritis caused by H. pylori, where TTP improvement was dependent on H. pylori infection eradication.
Databáze: OpenAIRE