The effect of prebiotics in the management of neonatal hyperbilirubinaemia
| Autor: | Giuseppe Riezzo, U. Corapi, M. Bisceglia, V Poerio, Flavia Indrio, Francesco Raimondi |
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| Přispěvatelé: | Bisceglia, M, Indrio, F, Riezzo, G, Poerio, V, Corapi, U, Raimondi, Francesco |
| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Pediatrics Bilirubin medicine.medical_treatment Oligosaccharides Breast milk Placebo Gastroenterology law.invention chemistry.chemical_compound Feces Randomized controlled trial Double-Blind Method law Polysaccharides Internal medicine medicine Humans Prospective Studies Prospective cohort study Infant Nutritional Physiological Phenomena Analysis of Variance business.industry Prebiotic Infant Newborn Repeated measures design General Medicine Infant Formula Prebiotics chemistry Infant formula Pediatrics Perinatology and Child Health Dietary Supplements Female Hyperbilirubinemia Neonatal business |
| Zdroj: | Acta paediatrica (Oslo, Norway : 1992). 98(10) |
| ISSN: | 1651-2227 |
| Popis: | Background: Breast milk oligosaccharides such as galacto-oligosaccharides (scGOS) and fructo-oligosaccharides (lcFOS) can influence the intestinal microbial flora. The latter, in turn, can modulate several intestinal and extraintestinal functions, including bilirubin metabolism. Supplementing infant formula with a prebiotic mixture might then be a novel and safe intervention to manage mild neonatal hyperbilirubinaemia. Aim: To investigate the effect of dietary supplementation with prebiotics on moderate hyperbilirubinaemia in healthy, term infants. Methods: A prospective, double-blind, clinical trial was performed on seventy-six consecutive newborns who were randomly assigned to receive a formula containing 0.8 g/dL of a mixture from scGOS and lcFOS (ratio 9:1), or maltodextrines as placebo for 28 days. Bilirubin levels were determined by the transcutaneous bilirubin measurement within 2 h after birth (T1), at 24, 48 and 72 h and at 5, 7, 10 and 28 days of life. The number of stool per day was also recorded. Results: Neonates receiving prebiotics showed a larger number of stools over all the duration of dietary intervention compared to that of those on placebo (Repeated Measures ANOVA p |
| Databáze: | OpenAIRE |
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