COMT Val158Met and BDNF C270T polymorphisms in schizophrenia: a case-control study
| Autor: | Paolo Stratta, Antonio Vita, Giovanni Severino, Paolo Cassano, Mario Maj, Alessandro Rossi, Giordano Invernizzi, Paola Piccardi, Armida Mucci, Maria Del Zompo, Silvana Galderisi, Stefano Pini, Brian Kirkpatrick |
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| Přispěvatelé: | Galderisi, Silvana, Maj, Mario, Kirkpatrick, B, Piccardi, P, Mucci, Armida, Invernizzi, G, Rossi, A, Pini, S, Vita, A, Cassano, P, Stratta, P, Severino, G, DEL ZOMPO, M. |
| Rok vydání: | 2005 |
| Předmět: |
Psychosis
medicine.medical_specialty Genotype Genetic Linkage Nerve Tissue Proteins Catechol-O-methyl transferase gene Catechol O-Methyltransferase behavioral disciplines and activities Polymorphism (computer science) Neurotrophic factors Internal medicine mental disorders medicine Humans Alleles Biological Psychiatry Genetics Brain-derived neurotrophic factor Polymorphism Genetic Catechol-O-methyl transferase Brain-Derived Neurotrophic Factor Case-control study medicine.disease Diagnostic and Statistical Manual of Mental Disorders Psychiatry and Mental health Endocrinology nervous system Schizophrenia Psychology Brain-derived neurotrophic factor gene |
| Zdroj: | Università degli Studi di Brescia-IRIS |
| ISSN: | 0920-9964 |
| Popis: | In a multicenter study involving 217 subjects of European ancestry [106 patients with schizophrenia and 111 healthy subjects], we tested the hypothesis that the catechol- O -methyl transferase (COMT) Val 158 Met and/or the brain-derived neurotrophic factor (BDNF) C 270 T gene polymorphisms are associated with schizophrenia. The COMT and BDNF genotype and their allele distribution did not differ between patients with schizophrenia and healthy comparison subjects. These results do not support the hypothesis that the COMT Val 158 Met or BDNF C 270 T gene polymorphisms are associated with liability to schizophrenia. |
| Databáze: | OpenAIRE |
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