Variation in the human leukocyte antigen (HLA) system and risk for endemic Burkitt Lymphoma in Northern Uganda
| Autor: | Patrick Kerchan, Moses Joloba, Murielle Verboom, Sam M. Mbulaiteye, Rainer Blasczyk, Ludmila Prokunina-Olsson, James J. Goedert, Leona W. Ayers, Robert J. Biggar, Ivan Mwebaza, Olusegun O. Onabajo, Hadijah Nabalende, Martin D. Ogwang, Samuel Kirimunda, Tobias Kinyera, Kishor Bhatia, Isaac Otim, Ismail D. Legason, Mark Ssennono, Steven J. Reynolds, Michael Hallensleben |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Human leukocyte antigen medicine.disease_cause Article Serology 03 medical and health sciences 0302 clinical medicine HLA Antigens Risk Factors Internal medicine Epidemiology medicine Humans Uganda Child business.industry Infant Newborn Infant Hematology Odds ratio medicine.disease Epstein–Barr virus Burkitt Lymphoma Confidence interval Lymphoma 030220 oncology & carcinogenesis Child Preschool Female business Malaria 030215 immunology |
| Zdroj: | Br J Haematol |
| Popis: | Endemic Burkitt lymphoma (eBL) is an aggressive childhood B-cell lymphoma associated with Plasmodium falciparum (Pf) malaria and Epstein-Barr virus (EBV) infections. Variation in the Human Leukocyte Antigen (HLA) system is suspected to play a role, but assessments using less accurate serology-based HLA typing techniques in small studies yielded conflicting results. We studied 200 eBL cases and 400 controls aged 0-15 years enrolled in northern Uganda and typed by accurate high-resolution HLA sequencing methods. HLA results were analyzed at one- or two-field resolution. Odds ratios and 95% confidence intervals (aOR, 95% CI) for eBL risk associated with common HLA alleles versus alleles that were rare ( |
| Databáze: | OpenAIRE |
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