Quantitative and qualitative analysis of metabolic response at interim positron emission tomography scan combined with International Prognostic Index is highly predictive of outcome in diffuse large B-cell lymphoma
| Autor: | Nathalie Nols, Anne Sonet, Thierry Vander Borght, Eric Van Den Neste, Lucienne Michaux, Nicolas Mounier, André Bosly, Marc André, Marie-Christiane Vekemans, S. Costantini, Renaud Lhommel, Salima Bouazza |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Standardized uptake value Aggressive lymphoma Sensitivity and Specificity International Prognostic Index Text mining Fluorodeoxyglucose F18 hemic and lymphatic diseases Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Aged Bone Marrow Transplantation Neoplasm Staging Hematology medicine.diagnostic_test business.industry Middle Aged medicine.disease Prognosis Lymphoma Treatment Outcome Oncology Positron emission tomography Positron-Emission Tomography Lymphoma Large B-Cell Diffuse Nuclear medicine business Tomography X-Ray Computed Diffuse large B-cell lymphoma |
| Zdroj: | Leukemialymphoma. 55(4) |
| ISSN: | 1029-2403 |
| Popis: | The prognostic value of interim (18)fluorodeoxyglucose positron emission tomography (i-PET) was investigated in 73 patients (median age 60 years) with diffuse large B-cell lymphoma (DLBCL). i-PET was analyzed using the Deauville score (DS) and change in maximum standardized uptake value (ΔSUV(max)). Patients with a DS of 1-3 demonstrated a significantly (p0.0001) better outcome (median follow-up 2.4 years) than patients with a score of 4 or 5 in terms of event-free survival (EFS) (79% vs. 36%), progression-free survival (PFS) (84% vs. 47%) and overall survival (OS) (91% vs. 51%). EFS (73% vs. 42%), PFS (78% vs. 50%) and OS (88% vs. 56%) were also significantly (p = 0.023) different between patients with ΔSUV(max)66% or ≤ 66%. Patients (n = 33) combining a favorable age-adjusted International Prognostic Index (IPI) (0 or 1) and a negative i-PET either by DS or ΔSUV(max) criteria showed a particularly good outcome (EFS: 85%, PFS: 88%, OS: 94%). Overall, i-PET was highly and independently predictive of any outcome, and its negative predictive value was improved by combination with IPI. |
| Databáze: | OpenAIRE |
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