Protein folding as a nonlinear nonequilibrium thermodynamic process
| Autor: | E. M. Popov |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Protein Folding
Quantitative Biology::Biomolecules Protein Conformation Chemistry Entropy Numerical analysis Clinical Biochemistry Proteins Non-equilibrium thermodynamics Cell Biology Biochemistry Protein Structure Tertiary Nonlinear system Genetics Thermodynamics Physical chemistry Protein folding Downhill folding Statistical physics Oligopeptides Molecular Biology Native structure Thermodynamic process |
| Zdroj: | IUBMB Life. 47:443-453 |
| ISSN: | 1521-6543 |
| Popis: | Biofurcational theory of protein folding is developed describing the process of formation of protein native structure as a sequence of non-equilibrium irreversible fluctuations, specific for a particular protein. The model gives explaination to all characteristic features of the folding process: stochastic mechanism, short time and precision of proteins self-assembling. A constructiwe role of entropy in the formation of a highly ordered structure out of disorder is discussed. A numerical method of a priori calculations of polypeptide structures basing on principles of bifractional folding model is presented. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text