Influence of the central-to-peripheral arterial stiffness gradient on the timing and amplitude of wave reflections
| Autor: | Yasmin, Ian B. Wilkinson, Stacey S. Hickson, Wilmer W. Nichols, John R. Cockcroft, Barry J. McDonnell, Carmel M. McEniery |
|---|---|
| Přispěvatelé: | Wilkinson, Ian [0000-0001-6598-9399], McEniery, Carmel [0000-0003-3636-0705], Apollo - University of Cambridge Repository |
| Rok vydání: | 2015 |
| Předmět: |
musculoskeletal diseases
Male medicine.medical_specialty animal structures Pulse Wave Analysis Physiology pulse wave velocity Pulsatile flow Blood Pressure macromolecular substances 030204 cardiovascular system & hematology augmentation index Article wave reflection 03 medical and health sciences 0302 clinical medicine Vascular Stiffness Internal medicine Internal Medicine medicine Humans 030212 general & internal medicine Pulse wave velocity arterial stiffness gradient Aorta Aged Physics Leg technology industry and agriculture Elastic artery Middle Aged medicine.disease equipment and supplies Peripheral body regions Femoral Artery Amplitude Carotid Arteries Pulsatile Flow Reflection (physics) Arterial stiffness Cardiology Arm Female Cardiology and Cardiovascular Medicine central pulse pressure |
| Zdroj: | Hypertension research : official journal of the Japanese Society of Hypertension. 39(10) |
| ISSN: | 1348-4214 |
| Popis: | In individuals with compliant aortas, peripheral muscular artery stiffness exceeds central elastic artery stiffness. With aging, central stiffness increases with little change in peripheral stiffness, resulting in a reversal of the normal stiffness gradient. This reversal may reduce the wave reflection amplitude due to the movement of the major 'effective' reflection site further from the heart. To test this phenomenon, we investigated the relationship among arterial stiffness gradients (normal and reversed), wave reflection amplitude and reflection site distance. Subjects aged ⩾50 years were recruited from the Anglo-Cardiff Collaborative Trial. Central stiffness was assessed by carotid-femoral pulse wave velocity (cfPWV). In Study 1, peripheral PWV was also measured in the arm (carotid-radial pulse wave velocity) and, in Study 2, in the leg (femoral-dorsalis pedis). Reflection site distance was calculated from cfPWV and the reflected wave Tr. Subjects were dichotomized into those with a normal stiffness gradient (peripheral >central PWV) or a reversed gradient (peripheral |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink