Effects of Pioglitazone or Exercise in Older Adults with Mild Cognitive Impairment and Insulin Resistance: A Pilot Study
| Autor: | Jim Grigsby, Kerry L. Hildreth, Karin F. Hoth, Pamela Wolfe, Sunny A. Linnebur, Robert S. Schwartz, Rachael E. Van Pelt, John Kittelson, Jennifer M. Trujillo, Kerrie L. Moreau, Christina L. Aquilante, Bennett Parnes, Tammie Nakamura, Victoria S. Pelak, C. Alan Anderson |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Cognitive Neuroscience lcsh:Geriatrics lcsh:RC346-429 03 medical and health sciences 0302 clinical medicine Insulin resistance Endurance training Internal medicine medicine 030212 general & internal medicine Effects of sleep deprivation on cognitive performance Original Research Article Cognitive impairment Exercise lcsh:Neurology. Diseases of the nervous system Pioglitazone business.industry VO2 max Mild cognitive impairment Cognition medicine.disease Obesity Psychiatry and Mental health lcsh:RC952-954.6 Physical therapy business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Dementia and Geriatric Cognitive Disorders Extra, Vol 5, Iss 1, Pp 51-63 (2015) Dementia and Geriatric Cognitive Disorders EXTRA |
| ISSN: | 1664-5464 |
| Popis: | Aims: To examine the effects of pioglitazone or endurance exercise training on cognitive function in older adults with mild cognitive impairment (MCI) and insulin resistance. Methods: Seventy-eight adults (mean age ± SD: 65 ± 7 years) with central obesity and MCI were randomized to 6 months of endurance exercise, pioglitazone or control. Results: Sixty-six participants completed the study. Exercise training did not significantly increase peak oxygen uptake compared to control (p = 0.12). Compared to control, insulin resistance improved in the pioglitazone group (p = 0.002) but not in the exercise group (p = 0.25). There was no measureable effect of pioglitazone or exercise on cognitive performance compared to control. Conclusion: In this pilot study, pioglitazone improved insulin resistance but not cognitive performance in older adults with MCI and insulin resistance. |
| Databáze: | OpenAIRE |
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