Is there a correlation between taurine levels and xenobioticinduced perturbations in protein synthesis?: A study with tetracycline in rats
| Autor: | John A. Timbrell, S Patel, Catherine J. Waterfield, Daniel S. Asker |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Male
medicine.medical_specialty Taurine Tetracycline Urinary system Clinical Biochemistry Drinking Serum albumin Cycloheximide Biochemistry Xenobiotics Excretion chemistry.chemical_compound Leucine Internal medicine medicine Animals Sulfhydryl Compounds Rats Wistar Muscle Skeletal Dose-Response Relationship Drug biology Body Weight Organic Chemistry Organ Size Glutathione Rats Proteinuria Endocrinology Liver chemistry Protein Biosynthesis biology.protein medicine.drug |
| Zdroj: | Amino Acids. 15:161-177 |
| ISSN: | 1438-2199 0939-4451 |
| DOI: | 10.1007/bf01345289 |
| Popis: | Changes in urinary levels of taurine have been reported in rats following treatment with various xenobiotics including those which alter protein synthesis and/or are hepatotoxic. This paper reports on the time course of the urinary elevation of taurine following treatment of rats with tetracycline (50, 150 and 200 mg.kg-1). Maximum taurine excretion occurred 8-12 h following dosing. Serum albumin and total protein were significantly lower after 24 h (200 mg.kg-1). The increase in urinary taurine was dose-related and reflected in the raised serum levels of taurine 24 h after dosing. Serum and urinary protein and [3H]-leucine incorporation into acid precipitable protein in liver and muscle were reduced by tetracycline (100, 150 and 200 mg.kg-1) 10 h after dosing. The reduction in protein synthesis was correlated with increased urinary and serum levels of taurine at 10 h. The use of taurine as a non-invasive marker of protein synthesis is discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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