Cardiorespiratory fitness in long-term lymphoma survivors after high-dose chemotherapy with autologous stem cell transplantation
| Autor: | Harald Holte, Stein Kvaløy, Knut B. Smeland, Cecilie E. Kiserud, Svend Aakhus, Lee W. Jones, Ingerid Arbo, Klaus Murbraech, Lene Thorsen, May Brit Lund, Jo S Stenehjem |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Oncology Cancer Research medicine.medical_specialty autologous stem cell transplantation Colorectal cancer medicine.medical_treatment physical activity Antineoplastic Agents Hematopoietic stem cell transplantation Pulmonary function testing 03 medical and health sciences 0302 clinical medicine Autologous stem-cell transplantation Internal medicine medicine Humans late effects Survivors Lung cancer cardiorespiratory fitness Dose-Response Relationship Drug lymphoma survivors business.industry Lymphoma Non-Hodgkin Hematopoietic Stem Cell Transplantation Cardiorespiratory fitness Middle Aged medicine.disease Hodgkin Disease Physical activity level 030220 oncology & carcinogenesis Heart failure Clinical Study Female business human activities 030215 immunology |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| DOI: | 10.1038/bjc.2016.180 |
| Popis: | Background: Cardiorespiratory fitness as measured by peak oxygen consumption (VO2peak) is a strong predictor of longevity and may be compromised by anticancer therapy, inactivity, and smoking. We compared VO2peak among lymphoma survivors (LSs) with reference data from healthy sedentary subjects, after a 10.2-year (mean) follow-up post high-dose chemotherapy with autologous stem cell transplantation (HDT-ASCT). We further examined the association between VO2peak and treatment, physical activity, smoking, pulmonary, and cardiac function. Methods: Lymphoma survivors treated with HDT-ASCT in Norway 1987–2008 were eligible. VO2peak was assessed by cardiopulmonary exercise testing. Pulmonary function testing and echocardiography were also conducted. Data on treatment, physical activity, and smoking were collected from hospital records and questionnaires. VO2peak was compared with age–sex predicted reference data. Linear regression was used to associate clinical factors with VO2peak cross-sectionally. Results: A total of 194 LSs without heart failure were studied. Mean VO2peak was 4.5% and 7.7% below norms in females and males, respectively. Twenty-two percent had impaired ( |
| Databáze: | OpenAIRE |
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