Potent and selective isophthalamide S2 hydroxyethylamine inhibitors of BACE1

Autor:	Timothy E. Benson, Michael J. Bienkowski, Tenbrink Ruth E, Alice Laborde, D. Bryan Prince, Joseph B. Moon, Steven W. Kortum, Thomas L. Emmons, Alfredo G. Tomasselli, Donna J. Paddock
Rok vydání:	2007
Předmět:	Molecular model medicine.drug_class Stereochemistry Clinical Biochemistry Pharmaceutical Science Cathepsin D Carboxamide Biochemistry Chemical synthesis Mice Structure-Activity Relationship mental disorders Drug Discovery Ethylamines medicine Animals Aspartic Acid Endopeptidases Humans Ifosfamide Enzyme Inhibitors Molecular Biology Mice Knockout Cathepsin biology Chemistry Hydrogen bond Organic Chemistry Hydrogen Bonding Models Chemical Enzyme inhibitor Drug Design biology.protein Molecular Medicine Amyloid Precursor Protein Secretases Selectivity
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 17:3378-3383
ISSN:	0960-894X
DOI:	10.1016/j.bmcl.2007.03.096
Popis:	The design and synthesis of a novel series of potent BACE1 hydroxyethylamine inhibitors. These inhibitors feature hydrogen bonding substituents at the C-5 position of the isophthalamide ring with improved selectivity over cathepsin D.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::329853e7edfb397bc11c47aeb2ba4871 https://doi.org/10.1016/j.bmcl.2007.03.096 Zobrazit plný text záznamu Full Text from ScienceDirect