Histological evaluation disqualifies IMT and calcification scores as surrogates for grading coronary and aortic atherosclerosis
| Autor: | Sander Verhage, Jan H.N. Lindeman, Ad J.J.C. Bogers, Antoon J. van den Bogaerdt, Jaap F. Hamming, Armelle J.A. Meershoek, Rogier A. van Dijk, Alexander F. Schaapherder |
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| Přispěvatelé: | Cardiothoracic Surgery |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Histology H&E stain Aortic Diseases Coronary Artery Disease 030204 cardiovascular system & hematology Carotid Intima-Media Thickness Coronary artery disease 03 medical and health sciences 0302 clinical medicine Internal medicine medicine.artery medicine Humans 030212 general & internal medicine Heart valve cardiovascular diseases Vascular Calcification Aortic atherosclerosis Coronary calcium Aorta business.industry Middle Aged medicine.disease Atherosclerosis Classification Coronary arteries Intima media thickness medicine.anatomical_structure Intima-media thickness Cardiology cardiovascular system Female business Cardiology and Cardiovascular Medicine Calcification |
| Zdroj: | International Journal of Cardiology, 224:328. Elsevier Ireland Ltd International Journal of Cardiology, 224, 328-334 |
| ISSN: | 0167-5273 |
| Popis: | Background/objectivesCarotid intimal media thickness (IMT) and coronary calcium scores (CCS) are thought to reflect atherosclerotic burden. The validity of this assumption for IMT is challenged by recent meta-analyses; for CCS by absence of a relationship between negative scores, and freedom of future events. As such, we considered evaluation of the relationship between tissue IMT and CCS, and extend of atherosclerotic disease relevant.MethodsAnalyses were performed on donor aortas obtained during renal graft procurement, and on coronary arteries collected during heart valve procurement for tissue donation. Movat pentachrome and Hematoxylin staining was performed, and the degree of atherosclerosis histologically graded. IMT and presence of calcium deposits were quantified on graded tissue sections.Results304 aortas and 185 coronary arteries covering the full atherosclerotic spectrum were evaluated. Aortas and coronaries showed similar relationships between tissue IMT and degree of atherosclerosis, with gradual increase in tissue IMT during earlier phases of atherosclerosis (r=0.68 and r=0.30, P |
| Databáze: | OpenAIRE |
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