lincR-Ccr2-5′AS and THRIL as potential biomarkers of multiple sclerosis
| Autor: | Shereen Rashad Mohammed, Asmaa Mohammed Mohammed, Olfat G. Shaker, Amr Hassan |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
lcsh:QH426-470 Central nervous system Multiple sclerosis Pathogenesis 03 medical and health sciences lncRNA 0302 clinical medicine Downregulation and upregulation Demyelinating disease medicine Optic neuritis Genetics (clinical) lcsh:R5-920 Expanded Disability Status Scale business.industry lincR-Ccr2-5′AS medicine.disease Fold change lcsh:Genetics 030104 developmental biology medicine.anatomical_structure Immunology THRIL lcsh:Medicine (General) business 030217 neurology & neurosurgery |
| Zdroj: | Egyptian Journal of Medical Human Genetics, Vol 22, Iss 1, Pp 1-9 (2021) |
| ISSN: | 2090-2441 |
| DOI: | 10.1186/s43042-021-00151-2 |
| Popis: | Background Multiple sclerosis (MS) is a demyelinating disease affecting the central nervous system (CNS). Long non-coding RNAs (lncRNAs) were believed to play a role in the pathogenesis of neurological disorders including MS. lincR-Ccr2-5′AS is expressed in the T helper2 (Th2) lineage. TNF-α heterogeneous nuclear ribonucleoprotein L (THRIL) causes the induction of TNF-α and regulates innate immune response and inflammation. We investigated the expression of lincR-Ccr2-5′AS and THRIL in MS to clarify their association with MS risk and the clinical features. Results LincR-Ccr2-5′AS was significantly downregulated in MS patients (fold change = 0.43±0.29, p = 0.03). The expression level was significantly low in patients with motor weakness and optic neuritis, patients with Expanded Disability Status Scale (EDSS) ≥5.5, and treatment-naïve patients. THRIL was significantly upregulated in MS patients (fold change = 6.18±2, p = 0.02). Its expression was significantly higher in patients with relapsing-remitting multiple sclerosis (RRMS), patients with motor weakness, patients with EDSS ≤5, and patients who received interferon. Conclusion Our results showed the downregulation of lincR-Ccr2-5′AS and the upregulation of lncRNA THRIL in MS patients. This differential expression of both lncRNAs may have an important role in MS pathogenesis. |
| Databáze: | OpenAIRE |
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