Dissociation of sodium-chloride cotransporter expression and blood pressure during chronic high dietary potassium supplementation
| Autor: | Robert Little, Sathish K. Murali, Søren B. Poulsen, Paul R. Grimm, Adrienne Assmus, Lei Cheng, Jessica R. Ivy, Ewout J. Hoorn, Vladimir Matchkov, Paul A. Welling, Robert A. Fenton |
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| Přispěvatelé: | Internal Medicine |
| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Little, R, Murali, S K, Poulsen, S B, Grimm, P R, Assmus, A, Cheng, L, Ivy, J R, Hoorn, E J, Matchkov, V, Welling, P A & Fenton, R A 2023, ' Dissociation of sodium-chloride cotransporter expression and blood pressure during chronic high dietary potassium supplementation ', JCI Insight, vol. 8, no. 5, e156437 . https://doi.org/10.1172/jci.insight.156437 JCI insight, 8(5):e156437. The American Society for Clinical Investigation Little, R, Murali, S K, Poulsen, S B, Grimm, P R, Assmus, A, Cheng, L, Ivy, J R, Hoorn, E J, Matchkov, V V, Welling, P A & Fenton, R A 2023, ' Dissociation of sodium-chloride cotransporter expression and blood pressure during chronic high dietary potassium supplementation ', JCI Insight . https://doi.org/10.1172/jci.insight.156437 |
| ISSN: | 2379-3708 |
| Popis: | Dietary potassium (K+) supplementation is associated with a lowering effect in blood pressure (BP), but not all studies agree. Here, we examined the effects of short- and long-term K+ supplementation on BP in mice, whether differences depend on the accompanying anion or the sodium (Na+) intake and molecular alterations in the kidney that may underlie BP changes. Relative to the control diet, BP was higher in mice fed a high NaCl (1.57% Na+) diet for 7 weeks or fed a K+free diet for 2 weeks. BP was highest on a K+-free/high NaCl diet. Commensurate with increased abundance and phosphorylation of the thiazide sensitive sodium-chloride-cotransporter (NCC) on the K+-free/high NaCl diet, BP returned to normal with thiazides. Three weeks of a high K+ diet (5% K+) increased BP (predominantly during the night) independently of dietary Na+ or anion intake. Conversely, 4 days of KCl feeding reduced BP. Both feeding periods resulted in lower NCC levels but in increased levels of cleaved (active) α and γ subunits of the epithelial Na+ channel ENaC. The elevated BP after chronic K+ feeding was reduced by amiloride but not thiazide. Our results suggest that dietary K+ has an optimal threshold where it may be most effective for cardiovascular health. |
| Databáze: | OpenAIRE |
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