Infectious agents in coronary lesions obtained by endatherectomy: pattern of distribution, coinfection, and clinical findings
| Autor: | Naami A, Bruno J. Messmer, S. Handt, Peter W. Radke, Sabine Merkelbach-Bruse, Hilmar Dörge, Vogel G, vom Dahl J, Peter Hanrath |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Male
Pathology medicine.medical_specialty medicine.medical_treatment Congenital cytomegalovirus infection Cytomegalovirus Coronary Artery Disease Endarterectomy Coronary Angiography Lesion Restenosis Angioplasty medicine Humans Angina Unstable Prospective Studies Aged Chlamydia Helicobacter pylori biology Unstable angina business.industry General Medicine Chlamydophila pneumoniae Middle Aged biology.organism_classification medicine.disease Coronary Vessels Coinfection Female medicine.symptom Cardiology and Cardiovascular Medicine business |
| Zdroj: | Coronary Artery Disease. 12:1-6 |
| ISSN: | 0954-6928 |
| Popis: | BACKGROUND Cytomegalovirus (CMV), Chlamydia pneumoniae (C. pneumoniae), and Helicobacter pylori (H. pylori) have been implicated in atherosclerosis and restenosis after angioplasty. The patterns of distribution within coronary lesions and possible coinfections of these pathogens in the coronary vasculature had not previously been evaluated. DESIGN A prospective, observational clinical study. METHODS Large coronary specimens (9-105 mm long) were obtained by endatherectomy of 53 patients undergoing aortocoronary bypass surgery. Samples were taken from two different sites of every lesion, resulting in a total of 106 probes. Presence of each pathogen was determined by polymerase chain reaction, subsequent hybridization, and DNA sequencing. RESULTS Cytomegalovirus and C. pneumoniae were detected in 30 and 32% of the samples, respectively; H. pylori was not detectable. The pathogens were not homogeneously distributed. A concurrent infection with both pathogens was observed in five of 106 (5%) lesions and five of 53 (9%) patients. Restenotic lesions were more often found in specimens in which cytomegalovirus was detected (five of 16 versus two of 37). Patients with C. pneumoniae-positive coronary lesions more commonly presented with unstable angina. CONCLUSIONS Inhomogeneous infections with cytomegalovirus and C. pneumoniae of coronary atherosclerotic lesions are found to be prevalent when serial analysis is performed. Concurrent infection with both pathogens occurs coincidentally; however, possible clinical implications of this new observation and the pathogenic impact on atherosclerosis need further investigation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|