Oral drug dosage forms administered to hospitalized children: Analysis of 117,665 oral administrations in a French paediatric hospital over a 1-year period
| Autor: | Yanis Mimouni, V. Bréant, Pierre Cochat, Emilie Henin, J.M. Sapori, A. Lajoinie, Ka Nguyen, Behrouz Kassai, Salma Malik |
|---|---|
| Přispěvatelé: | Evaluation et modélisation des effets thérapeutiques, Département biostatistiques et modélisation pour la santé et l'environnement [LBBE], Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2015 |
| Předmět: |
Drug Utilization
Drug doses Pediatrics medicine.medical_specialty Adolescent [SDV]Life Sciences [q-bio] Pharmaceutical Science Administration Oral 030226 pharmacology & pharmacy Dosage form Unmet needs law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Anatomical therapeutic chemical 030225 pediatrics Medicine Humans Child ComputingMilieux_MISCELLANEOUS Dosage Forms business.industry Infant Newborn Infant Hospitals Pediatric 3. Good health Child Preschool France business Age appropriateness Oral retinoid |
| Zdroj: | International Journal of Pharmaceutics International Journal of Pharmaceutics, 2016, 500, pp.336-44. ⟨10.1016/j.ijpharm.2016.01.048⟩ International Journal of Pharmaceutics, Elsevier, 2016, 500, pp.336-44. ⟨10.1016/j.ijpharm.2016.01.048⟩ |
| ISSN: | 1873-3476 0378-5173 |
| Popis: | Selecting the most appropriate dosage form, that ensures safe administration and adherence of medications, is a major issue for children. Marketed drugs, however, have rarely been tested for their use in children. There is a need for more data on drug formulations administered to children to identify unmet needs, and drive future paediatric research. We observed, over a 12-month follow-up, 117,665 oral drug administrations to 1998 hospitalized children. Nine-tenths belonged to five Anatomical Therapeutic Chemical classes: Alimentary tract & metabolism, Nervous system, Cardiovascular system, Anti-infectives for systemic use and Blood & blood forming organs, one third of drug doses administered to school-age children and adolescents were liquids, and extemporaneous capsules were commonly used in younger children. Our study shows that despite the advantages of solid dosage forms and recent evidence from randomized controlled trials showing their acceptability in infants, they are seldom used in paediatric practice. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect