Mathematical basis for the measurement of absolute and fractional cardiac output with diffusible tracers by compartmental analysis methods
| Autor: | Charkes Nd |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Organ blood flow
Cardiac output Diphosphonates Basis (linear algebra) Chemistry Pharmacology toxicology Analytical chemistry Technetium Blood volume Blood flow Technetium Tc 99m Medronate Models Biological Diffusion Regional Blood Flow TRACER Animals Humans Pharmacology (medical) Cardiac Output General Pharmacology Toxicology and Pharmaceutics Biological system Mathematics Analysis method |
| Zdroj: | Journal of Pharmacokinetics and Biopharmaceutics. 12:517-524 |
| ISSN: | 0090-466X |
| DOI: | 10.1007/bf01060129 |
| Popis: | Using compartmental analysis methods, a mathematical basis is given for the measurement of absolute and fractional cardiac output with diffusible tracers. Cardiac output is shown to be the product of the blood volume and the sum of the rate constants of tracer egress from blood, modified by a factor reflecting transcapillary diffusibility, the transfer fraction. The return of tracer to the blood and distant (intracellular) events are shown to play no role in the solution. Fractional cardiac output is the ratio of the rate constant of tracer egress from blood to an organ, divided by the sum of the egress constants from blood. Predominantly extracellular ions such as sodium or bromide are best suited for this technique, although theoretically any diffusible tracer whose compartmental model can be solved may be used. It is shown that fractional cardiac output is independent of the transfer fraction, and therefore can be measured accurately by tracers which are not freely diffusible. |
| Databáze: | OpenAIRE |
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