Remodelling and Treatment of the Blood-Brain Barrier in Glioma
| Autor: | Hao-Fei Wang, Nanxiang Xiong, Hao Xu, Fangcheng Zhang, Wei Xiang, Xiaobing Jiang, Peng Fu, Hongyang Zhao, Yihao Wang, Songshan Chai, Jiajing Wang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Central nervous system Review Blood–brain barrier 03 medical and health sciences 0302 clinical medicine glioma Glioma medicine remodelling business.industry Abnormal blood vessels Treatment method blood-brain barrier medicine.disease Structure and function Clinical Practice 030104 developmental biology medicine.anatomical_structure Oncology blood-brain barrier-associated therapy 030220 oncology & carcinogenesis structural and functional changes cardiovascular system business Neuroscience |
| Zdroj: | Cancer Management and Research |
| ISSN: | 1179-1322 |
| DOI: | 10.2147/cmar.s288720 |
| Popis: | The blood-brain barrier (BBB) is an essential structure of the central nervous system (CNS), and its existence makes the local internal environment of the CNS a relatively independent structure distinct from other internal environments of the human body to ensure normal physiological and high stability of activities of the CNS. Changes in BBB structure and function are fundamental to the pathophysiology of many diseases. The occurrence and development of glioma are often accompanied by a series of changes in the structure and function of the internal environment, the most significant of which is remodelling of the BBB. The remodelling of the BBB usually leads to changes in the permeability of local microvessels, which provide certain favourable conditions for the occurrence and development of glioma. Meanwhile, the newly generated abnormal blood vessels and the remaining intact regions of the BBB also hinder the effects of drug treatments. Changes in permeability and structural function often lead to the creation of abnormally functioning vascular regions, which pose further treatment challenges. At present, therapeutic methods for glioma have not achieved satisfactory effects in clinical practice, and emerging therapeutic methods have not yet been widely used in clinical practice. In this review, we summarize the knowledge of remodelling of the BBB in the glioma environment, the type of changes that occur, and current BBB treatment methods and prospects for the treatment of glioma. |
| Databáze: | OpenAIRE |
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