The differential effects of PGE on the immune response in normal and immunosuppressed mice
| Autor: | M.Gabriella Santoro, Peter Leport, Vera del Gobbo, Thomas Simmet, Bernard M. Jaffe, Cartesio Favalli, Enrico Garaci |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Prostaglandins E
Synthetic T-Lymphocytes medicine.medical_treatment Immunology Splenectomy Cell Count Biology Serology Mice Immune system 16 16-Dimethylprostaglandin E2 medicine Animals Neoplasm Antibody-Producing Cells Melanoma Antilymphocyte Serum Immunosuppression Therapy Immunity Cellular Immunosuppression Thymectomy medicine.disease Mice Inbred C57BL Titer Cell Transformation Neoplastic Hemagglutinins Doxorubicin Antibody Formation Female lipids (amino acids peptides and proteins) Rabbits |
| Zdroj: | Cellular Immunology. 72:351-359 |
| ISSN: | 0008-8749 |
| DOI: | 10.1016/0008-8749(82)90483-x |
| Popis: | The effect of 16,16-dimethyl-PGE 2 -methyl ester (di-M-PGE 2 ) on humoral and cellular immunoresponsiveness has been compared in normal mice and in mice immunosuppressed by splenectomy and thymectomy plus antithymocyte serum (ATS). Splenectomy resulted in immunosuppression manifested by augmentation of B-16 melanoma growth; this stimulatory effect was reversed by di-M-PGE 2 . In animals immunosuppressed by thymectomy plus ATS, di-M-PGE 2 augmented the humoral and cellular immune responses; this was manifested by slowing of the growth of B-16 melanoma and by stimulating the number of plaque-forming cells, hemagglutinin titers, and delayed-hypersensitivity reactions to sheep erythrocytes. In contrast, in normal (nonthymectomized) mice, di-M-PGE 2 was mildly immunosuppressive. Finally, adriamycin-immunosuppressed normal mice and this suppression were reversed by the addition of di-M-PGE 2 to the treatment regimen. |
| Databáze: | OpenAIRE |
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