Management of vertebral osteomyelitis over an eight-year period: The UDIPROVE (UDIne PROtocol on VErtebral osteomyelitis)
| Autor: | Massimo Sponza, Elda Righi, Barbara Cadeo, Matteo Bassetti, Elena Graziano, Alessandro Russo, Alessia Carnelutti, Assunta Sartor |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Adult Male medicine.medical_specialty 030106 microbiology Standardized uptake value lcsh:Infectious and parasitic diseases C-reactive protein FDG-PET/CT MRI Vertebral biopsy Vertebral osteomyelitis C-reactive protein 03 medical and health sciences 0302 clinical medicine FDG-PET/CT MRI Vertebral biopsy Vertebral osteomyelitis Positron Emission Tomography Computed Tomography Biopsy medicine Clinical endpoint Humans lcsh:RC109-216 030212 general & internal medicine Aged medicine.diagnostic_test biology Bacteria business.industry Magnetic resonance imaging Osteomyelitis General Medicine Bacterial Infections Middle Aged medicine.disease Magnetic Resonance Imaging Spine Anti-Bacterial Agents Infectious Diseases Positron emission tomography Positron-Emission Tomography Etiology biology.protein Female Radiology business |
| Zdroj: | International Journal of Infectious Diseases, Vol 89, Iss, Pp 116-121 (2019) |
| Popis: | Objectives: Vertebral osteomyelitis (VO) is a compelling clinical entity for clinicians because of its insidious and indolent course, which makes diagnosis difficult. Methods: All patients with a suspected diagnosis of VO were analyzed over an 8-year period (January 2009 to January 2017). The UDIPROVE protocol (UDIne PROtocol on VErtebral osteomyelitis) was applied in all cases. The primary endpoint was the performance of the UDIPROVE protocol to obtain the causal bacteria of infection. Results: During the study period, 133 episodes of confirmed VO were observed. The etiology of infection was obtained in 73.6% of cases: 70.5% were gram-positive, 16.3% were gram-negative, and 13.2% were mycobacteria. 18F-Fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) showed that for tubercular VO, the median standard uptake value (SUV) was higher when compared with VO caused by other bacteria. Clinical cure at the end of therapy was reported in 85.7% of patients. Previous antimicrobial therapy and a delay of more than 5 days in performing biopsy were associated with an undiagnosed etiology of VO. Targeted antibacterial therapy and follow-up with FDG-PET/CT were associated with clinical cure at the end of therapy, while the involvement of more than two vertebrae and inadequate drainage were associated with failure. Conclusions: Rigorous application of the UDIPROVE protocol allowed the causative pathogens of VO to be obtained – at about twice the rate reported in the literature. The use of FDG-PET/CT for the follow-up of infection was more reliable when compared to magnetic resonance imaging (MRI). Keywords: Vertebral osteomyelitis, Vertebral biopsy, C-reactive protein, FDG-PET/CT, MRI |
| Databáze: | OpenAIRE |
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