Characterisation of children and adolescents with acute lymphoblastic leukaemia who presented without peripheral blood blasts at diagnosis

Autor: David Spencer Mangum, Johnathon D. Bishop, Yinmei Zhou, Cheng Cheng, Seth E. Karol, Jeffrey E. Rubnitz, Raul C. Ribeiro, Jun J. Yang, Charles G. Mullighan, Sima Jeha, Ching‐Hon Pui, Hiroto Inaba
Rok vydání: 2022
Předmět:
Zdroj: British Journal of Haematology. 200:338-343
ISSN: 1365-2141
0007-1048
DOI: 10.1111/bjh.18552
Popis: Of 1003 children with acute lymphoblastic leukaemia (ALL), 147 (14.7%) presented without peripheral blood blasts (PBB). While absence of PBB was not independently associated with survival outcomes when compared to those with PBB, patients without PBB had distinct genetic and clinical characteristics. Notably, we identified a novel genotype-phenotype relationship, in that the patients without PBB had a significantly higher incidence of hyperdiploid B-ALL, accounting for almost half of all patients without PBB (46.9% vs. 22.7%, p 0.001). Further, absence of PBB was associated with decreased rates of leukaemia involvement of the central nervous system (p 0.001).
Databáze: OpenAIRE
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