Individual differences are critical in determining modafinil-induced behavioral sensitization and cross-sensitization with methamphetamine in mice
| Autor: | Isabel M. Quadros, Maria Gabriela Menezes Oliveira, Karin M. Moreira, Aline da Costa Soeiro, Karina Possa Abrahao |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Time Factors media_common.quotation_subject Individuality Modafinil Context (language use) Motor Activity Pharmacology Behavioral sensitization Locomotor activity Open field Methamphetamine Mice Behavioral Neuroscience Conditioning Psychological mental disorders Avoidance Learning medicine Animals Benzhydryl Compounds Sensitization media_common Analysis of Variance Behavior Animal Dose-Response Relationship Drug Addiction Association Learning Fear medicine.anatomical_structure Exploratory Behavior Central Nervous System Stimulants Psychology medicine.drug |
| Zdroj: | Behavioural Brain Research. 233:367-374 |
| ISSN: | 0166-4328 |
| Popis: | Modafinil is a non-amphetaminic psychostimulant used therapeutically for sleep and psychiatric disorders. However, some studies indicate that modafinil can have addictive properties. The present study examined whether modafinil can produce behavioral sensitization in mice, an experience and drug-dependent behavioral adaptation, and if individual differences play a role in this process. We further tested context-related factors and cross-sensitization between modafinil and methamphetamine. Important individual differences in the behavioral sensitization of Swiss Albino mice were observed after repeated administration of 50 mg/kg modafinil (Experiment 1), or 1 mg/kg methamphetamine (Experiment 2). Only mice classified as sensitized subgroup developed clear behavioral sensitization to the drugs. After a withdrawal period, mice received challenges of modafinil (Experiment 1), or methamphetamine (Experiment 2) and locomotor activity was evaluated in the activity cages (previous context) and in the open field arena (new context) in order to evaluate the context dependency of behavioral sensitization. The expression of sensitization to modafinil, but not to methamphetamine, was affected by contextual testing conditions, since modafinil-sensitized mice only expressed sensitization in the activity cage, but not in the open field. Subsequently, locomotor cross-sensitization between methamphetamine and modafinil was assessed by challenging modafinil-pretreated mice with 1 mg/kg methamphetamine (Experiment 1), and methamphetamine-pretreated mice with 50 mg/kg modafinil (Experiment 2). We observed a symmetrical cross-sensitization between the drugs only in those mice that were classified as sensitized subgroup. Our findings indicate that repeated exposure to modafinil induces behavioral sensitization only in some animals by similar neurobiological, but not contextual, mechanisms to those of methamphetamine. |
| Databáze: | OpenAIRE |
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